Vashe Solution for Venous Ulcers

This trial tests the effectiveness and safety of Vashe solution compared to saline solution for treating leg ulcers with signs of infection. Vashe solution contains hypochlorous acid to help clean wounds, while saline solution is a saltwater mix often used for the same purpose. Individuals with a leg ulcer due to vein issues and at least three signs of inflammation, such as pain or redness, may qualify for this trial. Participants should have previously used compression therapy and agree to continue it during the trial. As an unphased trial, this study offers a unique opportunity to contribute to understanding new treatment options for leg ulcers.

The trial requires that you have not taken systemic antibiotics (medications that fight infections throughout the body) in the ten days before joining. Other medications are not specifically mentioned, so it's best to discuss your current medications with the trial team.

Research has shown that Vashe solution, containing hypochlorous acid, is generally safe for treating wounds. Studies and safety information indicate it is non-toxic and does not cause stinging. It effectively cleans and rinses wounds, such as ulcers and burns, without known harmful effects when used correctly. No long-term symptoms have been linked to its use, and it is not expected to be harmful if accidentally swallowed. However, individuals sensitive to hypochlorous acid should avoid it. Overall, research considers Vashe solution a safe choice for wound care.¹²³⁴⁵

Vashe solution is unique because it contains hypochlorous acid, which is known for its antimicrobial properties. Unlike traditional saline solutions that primarily serve to rinse and clean wounds, Vashe solution actively targets bacteria, potentially reducing infection risk in venous ulcers. Researchers are excited about this treatment because it offers a dual action by both cleansing the wound and providing an antibacterial effect, which could lead to faster healing and better outcomes for patients.

This trial will compare the effectiveness of Vashe solution and saline solution in treating venous ulcers. Studies have shown that Vashe solution, which contains hypochlorous acid, effectively heals wounds. Specifically, research indicates that 86% of wounds treated with Vashe solution healed, with reduced pain and odor. Another study found that wounds treated with hypochlorous acid solutions healed completely. The solution cleans the wound and reduces bacteria, aiding healing. It is considered more effective than saline for complex wounds, such as venous ulcers.²⁶⁷⁸⁹