Mindfulness Training for Depression

This trial aims to explore whether brief guided mindfulness practice using the Healthy Minds app can enhance the effects of a specific brain stimulation therapy (aiTBS) for people with major depressive disorder (MDD). Participants will use a smartphone app for daily mindfulness exercises while undergoing their usual aiTBS treatment. The researchers aim to assess the feasibility and acceptability of this approach and whether it improves mindfulness and mood over time. Suitable candidates for this trial have MDD, are already receiving aiTBS at MUSC, can speak English, and are willing to use a smartphone for mindfulness practice. As an unphased trial, this study offers a unique opportunity to contribute to innovative research that could enhance mental health treatments.

The trial information does not specify whether you need to stop taking your current medications. It focuses on adding mindfulness practice to your existing treatment.

Research has shown that mindfulness apps, such as the Healthy Minds app, can help reduce symptoms of depression and anxiety. However, meditating can be challenging. Studies indicate that 25% to 87% of people who meditate experience some negative effects, such as increased anxiety or restlessness. For a smaller group, between 3% and 37%, these effects can be more serious and may interfere with daily activities.

Researchers are excited about the Guided Mindfulness Practice using the Healthy Minds app for treating depression because it offers a non-pharmacological approach, making it different from traditional options like antidepressants and psychotherapy. Unlike medications that can come with side effects, mindfulness training focuses on enhancing mental well-being through meditation and awareness exercises. This method empowers individuals to manage their symptoms actively and may provide a sustainable, side-effect-free way to improve mood and mental health.

Research shows that mindfulness apps can help reduce symptoms of depression. In this trial, participants will use the Guided Mindfulness Practice through the Healthy Minds app during aiTBS. Studies have found that people using mindfulness apps experience small but meaningful drops in stress and depression. One review found that meditation apps, like the one under study, slightly improve depression symptoms. Another study highlighted the positive effects of mindfulness exercises guided by a smartphone app on both depression and anxiety. Overall, evidence supports the potential of mindfulness apps to positively impact mental health, including reducing depressive symptoms.¹⁵⁶⁷⁸