Prehabilitation for Ovarian Cancer Surgery

(ADAPT-OC Trial)

This trial explores the best way to prepare women for ovarian cancer surgery through a program called prehabilitation, which includes exercise, protein intake, and breathing exercises. Researchers aim to determine whether in-person, remote, or educational materials alone make the program easier and more effective for patients. Women scheduled for surgery due to suspected ovarian cancer, with no exercise restrictions, might be suitable candidates. Participants will track their progress using an app and may receive coaching to help them adhere to the program. The goal is to identify which method benefits patients the most before surgery. As an unphased trial, this study allows participants to contribute to innovative research that could enhance pre-surgery preparation for future patients.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research has shown that the prehabilitation treatments studied in this trial are generally safe. These programs, which include activities like exercise and nutrition support before surgery, help improve recovery and reduce complications afterward. Importantly, studies have not reported any serious side effects, indicating that participants did not experience major problems from the treatment.

For in-person prehabilitation, reviews show that these programs lead to better recovery after surgery and fewer complications. Similarly, the remote prehabilitation approach, which participants can do at home, has proven safe and effective, with participants following the program well and no major issues reported.

Researchers are excited about this trial because it explores a unique prehabilitation approach for ovarian cancer surgery. Unlike standard care, which typically focuses on postoperative recovery, this program aims to enhance patients' strength and resilience before surgery through comprehensive strategies like aerobic exercise, protein supplementation, stress management, and personalized coaching. The trial is testing both in-person and remote versions, offering flexibility and accessibility that could make it easier for patients to participate. By potentially improving surgical outcomes and recovery times, this approach could revolutionize how we prepare patients for major surgeries.

This trial will compare different approaches to prehabilitation for ovarian cancer surgery. Studies have shown that programs combining various types of preparation can benefit those preparing for surgery. Research indicates these programs can boost physical abilities, improve overall health, and enhance emotional well-being. For women with gynecologic cancer, such programs have led to an 8% improvement in oxygen utilization and a 20% increase in muscle strength. They also reduce complications after surgery and speed up recovery. Patients generally find these programs helpful and beneficial for surgery preparation.⁴⁶⁷⁸⁹