Vagus Nerve Stimulation for Knee Osteoarthritis

This trial explores whether stimulating a nerve in the ear can reduce knee pain and improve body functions in individuals with knee osteoarthritis. Researchers aim to determine if this method, known as transcutaneous vagus nerve stimulation (tVNS), is easy to use and affects pain perception and bodily response. Participants will undergo a 60-minute treatment and complete various assessments to measure changes in pain and satisfaction. The trial seeks individuals who have experienced knee pain for at least 3 months that worsens with activity and who can speak English. As an unphased trial, this study offers participants the chance to contribute to innovative research that could lead to new pain management solutions.

The trial information does not specify whether you need to stop taking your current medications. It is best to discuss this with the trial coordinators or your doctor.

Research has shown that using a device on the ear to stimulate a nerve, known as transcutaneous vagus nerve stimulation (tVNS), might safely treat knee osteoarthritis. Early results suggest that tVNS can reduce pain without causing serious side effects. In studies, participants generally tolerated it well, experiencing few side effects. Those who used tVNS on their ears reported less pain and improved movement. So far, tVNS appears to be a promising and safe option for managing knee pain.¹²³⁴⁵

Transcutaneous vagus nerve stimulation (tVNS) is unique because it offers a non-invasive approach to managing knee osteoarthritis pain. Unlike standard treatments like NSAIDs or corticosteroid injections, tVNS targets the vagus nerve at the ear, potentially modulating pain signals and reducing inflammation without the need for medications. Researchers are excited about this method because it may provide relief with fewer side effects and risks, making it an innovative option for people seeking alternatives to traditional therapies.

Research has shown that transcutaneous vagus nerve stimulation (tVNS) can reduce pain in individuals with knee osteoarthritis (OA). Studies have found that tVNS decreases knee sensitivity to pain, resulting in less discomfort for patients. Early data suggest that tVNS not only alleviates knee pain but also offers a safe treatment option. These findings indicate that tVNS might ease pain and improve autonomic functions like heart rate. Overall, early results are promising for tVNS as a treatment for knee OA pain.¹²³⁴⁶