Stellate Ganglion Block + Cognitive Processing Therapy for PTSD

(SGB Trial)

This trial explores a new PTSD treatment by combining Cognitive Processing Therapy (CPT) and Stellate Ganglion Block (SGB). CPT is a well-known therapy for PTSD, but many patients still experience symptoms after treatment. SGB involves a local anesthetic injection near the base of the neck to reduce stress signals. The study aims to determine if adding SGB to CPT improves outcomes. The trial seeks participants with PTSD who live in Illinois and are willing to engage in a week of daily therapy. As an unphased trial, it offers a unique opportunity to contribute to innovative PTSD treatment research.

The trial requires that you have been on a stable dose of psychotropic medication for at least one month before starting and that you do not plan to change your medications within three months of starting the study. If you are on blood-thinning medications, you cannot participate.

A previous study showed that the Stellate Ganglion Block (SGB) treatment for PTSD is safe and well-tolerated. This treatment involves an injection of numbing medicine at the base of the neck. Research indicates that this procedure is acceptable to patients and does not affect brain function. Studies have found that many patients experience quick improvement in their PTSD symptoms after receiving SGB. While no major safety concerns have been reported, discussing any concerns with a healthcare provider before joining a trial is always important.¹²³⁴⁵

Researchers are excited about the Stellate Ganglion Block (SGB) for PTSD because it offers a unique approach compared to traditional treatments like psychotherapy and medication. Unlike standard care options that primarily focus on altering brain chemistry or behavior over time, SGB targets the stellate ganglion, a group of nerves in the neck, to quickly reduce symptoms by interrupting the body's stress response. This method has the potential to deliver rapid relief, making it particularly appealing for individuals who need immediate symptom management. Additionally, when combined with Cognitive Processing Therapy, SGB could enhance the effectiveness of therapy by creating an optimal state for processing traumatic memories.

Studies have shown that Stellate Ganglion Block (SGB), a treatment tested in this trial, can help reduce PTSD symptoms. One study found that patients who received two SGB treatments experienced a significant drop in their PTSD symptoms. Another review indicated that SGB quickly improved symptoms for 70% to 75% of patients. This trial will compare SGB to a placebo treatment to determine its effectiveness. Researchers are also investigating whether combining SGB with Cognitive Processing Therapy (CPT), which already benefits many people with PTSD, could enhance treatment outcomes.²³⁶⁷⁸