6 Participants NeededMy employer runs this trial

Transcranial Magnetic Stimulation for Motor Deficits After Brain Tumor Surgery

RN
Overseen ByResearch Nurse Navigator
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether Transcranial Magnetic Stimulation (TMS), a technique using magnetic pulses, can aid in recovering movement abilities after brain tumor surgery. Surgery can sometimes unintentionally affect brain areas responsible for movement, making activities like walking or using hands difficult. The trial will include six patients with movement difficulties post-surgery, three with recent issues and three with long-term issues. Ideal candidates are those who have experienced movement problems after brain tumor surgery, either shortly after or up to three years later. As an unphased trial, this study offers patients the opportunity to contribute to groundbreaking research that could enhance recovery options for future patients.

Do I have to stop taking my current medications for the trial?

The trial protocol does not specify whether you need to stop taking your current medications. However, it mentions that patients undergoing any form of prior therapy, except previous TMS therapy, will be considered, suggesting you may not need to stop your medications.

What prior data suggests that Transcranial Magnetic Stimulation is safe for patients recovering from brain tumor surgery?

Research has shown that Transcranial Magnetic Stimulation (TMS) is generally safe for individuals who have undergone brain tumor surgery. TMS uses magnetic pulses to stimulate specific brain areas. Studies have found that patients usually tolerate it well. Evidence indicates that TMS has very few side effects, with no serious ones reported. This suggests that TMS could safely aid in helping patients regain movement abilities after surgery.12345

Why are researchers excited about this trial?

Transcranial Magnetic Stimulation (TMS) is unique because it offers a non-invasive way to improve motor function after brain tumor surgery, targeting specific brain areas with magnetic pulses. Unlike traditional rehabilitation that often requires lengthy therapy sessions, TMS can potentially deliver results after just three days of treatment. Researchers are excited about this approach because it uses precise image-guided stimulation to modulate brain activity, which could lead to faster and more significant recovery for patients with motor deficits.

What evidence suggests that Transcranial Magnetic Stimulation is effective for motor deficits after brain tumor surgery?

Studies have shown that transcranial magnetic stimulation (TMS) can improve movement in patients after brain tumor surgery. In this trial, participants will receive repetitive TMS (rTMS) to enhance movement abilities. Research indicates that rTMS significantly improved movement in patients with post-surgical movement problems. In another study, patients reported better use of their arms and legs after receiving TMS. This non-invasive treatment uses magnetic pulses to stimulate specific brain areas, aiding in the restoration of movement abilities. Overall, TMS has shown promise in aiding recovery from surgery-related movement issues.34567

Who Is on the Research Team?

BJ

Brian J Gill, MD

Principal Investigator

Columbia University

Are You a Good Fit for This Trial?

This trial is for adults aged 22-65 who have had brain tumor surgery and are experiencing ongoing movement problems (like weakness in arms or legs) within three years after surgery. Participants must be able to give consent, but can't join if they have certain medical devices, seizure history, severe heart disease, cognitive issues, or are pregnant.

Inclusion Criteria

I have had surgery and still have movement problems for less than three years.
I have had treatments before, except for TMS therapy.
Ability to understand and the willingness to sign a written informed consent document.
See 2 more

Exclusion Criteria

Pregnant or breast-feeding individuals.
Patients with implanted devices (e.g., pacemakers, implanted stimulators, intracranial electrodes, cochlear implants).
Active suicidal ideation or plan as assessed by the Columbia Suicide Severity Rating Scale.
See 6 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants receive TMS treatment once per day for three consecutive days

1 week
3 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

6 months
Visits at 1 week, 1 month, 3 months, and 6 months post-intervention

What Are the Treatments Tested in This Trial?

Interventions

  • Transcranial Magnetic Stimulation (TMS)

Trial Overview

The study tests whether transcranial magnetic stimulation (TMS), a non-invasive treatment using magnetic pulses on the brain, can help improve movement abilities after brain tumor surgery. Six patients will receive TMS daily for three days; their progress will be measured with standard motor function tests.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Transcranial magnetic stimulationExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Brian J.Gill

Lead Sponsor

Columbia University

Collaborator

Trials
1,529
Recruited
2,832,000+

Citations

a randomized, double-blind, sham-controlled trial

This study investigated the efficacy of repetitive navigated transcranial magnetic stimulation (rTMS) for treatment of motor deficits after supratentorial tumor ...

Brain tumor patient perceptions toward repetitive transcranial ...

Most Group 1 respondents reported a positive experience of rTMS (15/21). Patients experienced subjective improvements in gross motor functions of arm and leg ...

Postoperative navigated transcranial magnetic stimulation ...

Early postoperative nTMS may reliably predict long-term motor recovery of patients suffering from severe motor deficits immediately after resection of tumors ...

Assessing the Capabilities of Transcranial Magnetic ... - PMC

Another interesting application of the TMS could be in the prediction of motor deficits recovery after the brain tumor surgery. A study ...

Repetitive Transcranial Magnetic Stimulation for Enhancing ...

A technique called Transcranial Magnetic Stimulation (TMS) might help patients recover these lost abilities faster. What We're Doing: We're conducting a study ...

Current and potential utility of transcranial magnetic ... - PMC

This article describes the evolution and state-of-the-art of navigated transcranial magnetic stimulation for evaluation of patients with brain tumors.

NCT07530536 | rTMS for Postoperative Brain Tumor Patients

A technique called Transcranial Magnetic Stimulation (TMS) might help patients recover these lost abilities faster. The investigators are ...