High-Intensity Interval Training for Prostate Cancer

(ESCAPE Trial)

This trial explores how a short session of home-based high-intensity interval training (HIIT) affects hormone levels in men monitoring their low-grade prostate cancer without active treatment. Participants will complete an online HIIT workout consisting of six one-minute exercises. Men with localized prostate cancer who are not receiving treatment and can handle moderate-to-high intensity exercise may be suitable candidates. As an unphased trial, this study provides a unique opportunity to contribute to research that could enhance future prostate cancer management.

The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are using medications that affect steroid metabolism.

Research has shown that high-intensity interval training (HIIT) is generally safe for men with prostate cancer. Studies reported no serious negative effects from HIIT. Participants exercised intensely without major safety concerns. HIIT also improved fitness and reduced prostate-specific antigen (PSA) levels, which are important for prostate health. This suggests that HIIT is not only safe but might also help manage prostate cancer symptoms.¹²³⁴⁵

Unlike traditional treatments for prostate cancer, which often include surgery, radiation, hormone therapy, or chemotherapy, high-intensity interval training (HIIT) exercise offers a non-invasive approach. Researchers are excited about HIIT because it can be done at home, making it accessible and convenient. This method also aims to improve physical fitness and potentially enhance quality of life without the side effects associated with more aggressive treatments. Additionally, exercise may have beneficial effects on cancer progression through mechanisms like improved immune function and hormone regulation.

Research has shown that high-intensity interval training (HIIT) can benefit men with prostate cancer. Studies indicate that HIIT improves the heart and lungs' ability to supply oxygen during exercise. It also lowers levels of prostate-specific antigen (PSA), a protein produced by the prostate that can signal cancer progression. Some studies suggest that HIIT may slow prostate cell growth and improve overall cancer outcomes. These findings offer hope for using HIIT to manage prostate cancer. Participants in this trial will engage in a home-based HIIT exercise session, supervised online, and will collect saliva samples to further explore these potential benefits.¹³⁴⁵⁶