Platelet Poor Plasma Injections for Lower Extremity Injuries
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests whether a single injection of platelet-poor plasma (PPP) can enhance muscle healing after an injury compared to standard care alone. Researchers aim for PPP to reduce scar tissue and promote muscle growth following a lower body muscle strain, such as in the hamstring or quadriceps. Individuals injured within the last 10 days while playing sports and willing to undergo physical therapy may qualify. The trial compares two groups: one receives the PPP injection with standard care, and the other receives only standard care. As an unphased trial, this study provides a unique opportunity to contribute to groundbreaking research that could improve muscle recovery treatments.
Do I have to stop taking my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is there any evidence suggesting that platelet poor plasma injections are likely to be safe?
Research has shown that platelet-poor plasma (PPP) injections are generally safe and well-tolerated. In past studies, patients who received PPP returned to sports faster than those who received other treatments, such as platelet-rich plasma (PRP). This suggests that PPP not only aids in quicker recovery but also avoids major side effects that could hinder healing.
No serious problems have been reported from PPP injections in the studies reviewed. Patients typically experienced mild reactions at the injection site, such as temporary pain or swelling, which are common with most injections. Overall, the available safety information is reassuring for anyone considering participation in a trial involving PPP.12345Why do researchers think this study treatment might be promising?
Researchers are excited about Platelet Poor Plasma (PPP) injections for lower extremity injuries because they offer a novel approach by using a component of the patient's own blood. Unlike standard treatments that primarily focus on physical therapy and hematoma aspiration, PPP injections aim to enhance healing directly at the injury site with autologous material that might encourage tissue repair. This method could potentially lead to faster recovery times and improved healing outcomes, making it a promising alternative to traditional care pathways.
What evidence suggests that platelet poor plasma injections could be effective for lower extremity injuries?
Research has shown that platelet-poor plasma (PPP) injections can accelerate muscle healing after an injury. In this trial, participants in the PPP Injection Treated Arm will receive PPP injections. Studies have found that these injections can lead to a quicker return to sports compared to other treatments. PPP retains important growth factors that aid in healing while having fewer platelets, potentially reducing inflammation. Early results suggest that PPP can also reduce scar tissue and promote new muscle growth at the injury site. Overall, PPP appears to be a promising treatment for muscle injuries by promoting quicker and better healing.13567
Are You a Good Fit for This Trial?
This trial is for athletes aged 18 to 45 who have had a recent (within 10 days) muscle strain in their lower body, such as the hamstring or quadriceps, from sports activities. Participants must be willing to do physical therapy and follow standard care for their injury.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a single injection of platelet-poor plasma (PPP) into the acute muscle injury site, followed by physical therapy
Follow-up
Participants are monitored for changes in scar tissue volume and muscle regeneration through MRI analysis
What Are the Treatments Tested in This Trial?
Interventions
- Platelet Poor Plasma (PPP) Injection
Trial Overview
The study compares a single injection of platelet-poor plasma (PPP) into the injured muscle versus standard treatment with ultrasound-guided aspiration alone. The goal is to see if PPP helps muscles heal better over six months.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
US-guided aspiration of hematoma (if present) and injection of small volume (1-6cc's) of autologous platelet poor plasma (PPP) at the site of injury and post-injection physical therapy.
Standard of care pathway with US-guided aspiration of hematoma (if present) and physical therapy only.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Colorado, Denver
Lead Sponsor
Emory University
Collaborator
University of Iowa
Collaborator
Citations
Platelet-Poor Plasma for Muscle Injuries: A Review of ... - PMC
They found that PPP resulted in a faster RTS compared with leukocyte-rich PRP for acute thigh muscle injuries (included but not limited to ...
The Use of Platelet-Rich Plasma (PRP) and ...
Platelet-poor plasma (PPP), which preserves key growth factors while reducing platelet concentration, has emerged as a potential alternative.
3.
sjharchives.sclhealth.org
sjharchives.sclhealth.org/digital/api/collection/p17090coll25/id/1167/downloadPlatelet-Poor vs Platelet-Rich Plasma For The Treatment Of ...
What is New: This study is the first to demonstrate that PPP for the treatment of acute thigh muscle injuries results in faster return to sport compared to ...
Prospective Cohort Study of Athletes Following an Injection ...
We anticipate that PPP injections will lead to a measurable reduction in scar tissue and an increase in regenerated muscle tissue at the injury site over a six- ...
5.
journals.lww.com
journals.lww.com/acsm-csmr/fulltext/2024/06000/platelet_poor_versus_platelet_rich_plasma_for_the.5.aspxPlatelet-Poor versus Platelet-Rich Plasma for the ...
PRP has been identified as an effective treatment for multiple musculoskeletal conditions, including knee osteoarthritis, common extensor tendinopathy, rotator ...
Platelet Poor Plasma Injections for Lower Extremity Injuries
The investigators anticipate that PPP injections will lead to a measurable reduction in scar tissue and an increase in regenerated muscle tissue ...
The Role of Platelet-Rich Plasma Injection for Muscle Strains ...
The available evidence suggests that PRP might have a beneficial effect on the pain perceived by athletes following an acute muscle strain.
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