Twitch Amplitude for Intubation
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to determine the maximum ratio of the twitch amplitude (T1) to the reference twitch (Tref) amplitude (T1/Tref) that provides excellent intubating conditions.
Who Is on the Research Team?
J. Ross Renew, MD
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
This trial is for adults aged 18 or older who are willing to participate and can give informed consent. It is intended for people undergoing procedures that require intubation.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are intubated based on the T1/Tref ratio to determine intubating conditions
Follow-up
Participants are monitored for intubating conditions and neuromuscular block levels
What Are the Treatments Tested in This Trial?
Trial Overview
The study tests different levels of muscle response (twitch amplitude ratios: <0.1, <0.3, <0.5) to find which provides the best conditions for safely inserting a breathing tube during anesthesia.
How Is the Trial Designed?
3
Treatment groups
Experimental Treatment
Participants will be intubated once the ratio of the twitch amplitude to the reference twitch amplitude T1/Tref \<0.5 (shallower level of block)
Participants will be intubated once the ratio of the twitch amplitude to the reference twitch amplitude T1/Tref \<0.3 (intermediate depth of block)
Participants will be intubated once the ratio of the twitch amplitude to the reference twitch amplitude (T1/Tref) \<0.1 (deeper level of block)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
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