Goji Berry for Hot Flashes
(GOJI-VMS Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this clinical trial is to compare two forms of goji berry powder-whole goji berry powder and goji juice powder-in peri- and postmenopausal women aged 40-65 years who experience frequent vasomotor symptoms (hot flashes). The study aims to determine which formulation is more promising for a future larger trial by evaluating effects on HDL cholesterol function, vasomotor symptoms, cognitive performance, and participant acceptability.
The main questions it aims to answer are:
Does whole goji berry powder produce a greater improvement in HDL cholesterol efflux capacity (CEC) over 30 days compared with goji juice powder? Are changes in HDL function associated with changes in hot flash burden, cognitive performance, and self-reported cognitive symptoms?
Researchers will compare participants assigned to whole goji berry powder with participants assigned to goji juice powder to evaluate differences in HDL function, vasomotor symptoms, cognitive outcomes, and intervention acceptability.
Participants will:
Consume one mug cake containing their assigned goji powder daily for 30 days. Record hot flash frequency, duration, and severity using a smartphone-based electronic diary.
Attend study visits at baseline, Day 15, and Day 30. Provide fasting blood samples at baseline and Day 30 for assessment of HDL cholesterol efflux capacity and cardiometabolic biomarkers.
Complete computerized cognitive testing (TabCAT) at baseline and Day 30. Complete questionnaires assessing menopause-related quality of life, brain fog, mental alertness, physical activity, and study acceptability.
Are You a Good Fit for This Trial?
This trial is for women aged 40-65 who are peri- or postmenopausal and have frequent hot flashes. Participants should be generally healthy and able to attend study visits, use a smartphone diary, and provide blood samples.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants consume a standardized goji-containing mug cake daily for 30 days and complete study assessments
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Trial Overview
The study compares two forms of goji berry—whole powder vs. juice powder—taken daily in a mug cake for 30 days. Researchers will look at effects on cholesterol function, hot flashes, cognitive performance, and how acceptable participants find each form.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
In this arm, participants will consume goji berry powder
In this arm, participants consume goji berry juice powder
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Davis
Lead Sponsor
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