Tyrosol + Creatine for Exercise Performance and Cognition
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to evaluate the effects of creatine and tyrosol, both individually and combined, on exercise performance and brain function. Participants will be divided into groups to test creatine (a dietary supplement), a placebo, or both creatine and tyrosol (a natural compound). Researchers will assess endurance, strength, and mental sharpness before and after an 8-week period. Healthy men who exercise regularly and can maintain their current workout and diet routine may be suitable for this study. As an unphased trial, this study provides participants the chance to contribute to foundational research that could enhance exercise and cognitive performance.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
A previous study demonstrated that creatine monohydrate is very safe. A review of 685 clinical trials found no major safety concerns, indicating that creatine is generally well-tolerated with no significant side effects reported.
Regarding tyrosol, less safety information is available. However, studies using tyrosol with creatine found no harmful interactions. This suggests it might be safe to use with creatine, although further research could confirm this.
Overall, creatine has a strong safety record, while tyrosol appears safe when used with creatine, based on current information.12345Why are researchers excited about this trial's treatments?
Researchers are excited about combining Tyrosol and Creatine because it offers a fresh approach to boosting both exercise performance and cognitive function. Unlike standard supplements that typically focus on either physical or mental enhancements separately, this combination targets both areas simultaneously. Tyrosol, a natural antioxidant, may enhance brain health and protect against oxidative stress, while Creatine Monohydrate is well-known for improving muscle energy and strength. Together, they might offer a dual benefit that current options don't provide.
What evidence suggests that this trial's treatments could be effective for exercise performance and cognition?
Studies have shown that creatine can improve both physical and mental performance. It can increase muscle strength and endurance while reducing mental fatigue. Research indicates that creatine enhances strength in exercises like squats and leg presses. It also aids memory and decision-making, crucial for clear thinking. Tyrosol is known for reducing inflammation and protecting the brain, but less evidence exists regarding its impact on exercise performance. In this trial, participants will receive either a combination of Tyrosol and Creatine, Creatine with a placebo, or a placebo with another placebo. The researchers are studying these substances for their potential to enhance both exercise and mental abilities.678910
Who Is on the Research Team?
Eric Sikorski, PhD
Principal Investigator
Applied Science and Performance Institute
Are You a Good Fit for This Trial?
This trial is for healthy men aged 20-55 who exercise moderately or vigorously at least twice a week, have above-average fitness for their age, and can read and write in English. Participants must not use muscle-building supplements or have certain health conditions like heart, kidney, or metabolic diseases.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive daily supplementation of creatine, tyrosol, or placebo for 8 weeks, with repeated strength and endurance testing
Follow-up
Participants are monitored for muscle soreness and other outcomes after the treatment period
What Are the Treatments Tested in This Trial?
Interventions
- Creatine Monohydrate
- Tyrosol
Trial Overview
The study tests the effects of creatine alone, creatine plus tyrosol, and a placebo (resistant dextrin) on exercise performance and thinking skills over 8 weeks. It uses a randomized, double-blind design where neither participants nor researchers know which group anyone is in.
How Is the Trial Designed?
3
Treatment groups
Experimental Treatment
150mg Tyrosol (administered as 1 capsule, containing 150mg/capsule) + 5g of Creatine Monohydrate powder; taken daily
5g of resistant dextrin powder (placebo) + 150mg Resistant dextrin capsules (administered as 1 capsule, containing 150mg/capsule) (placebo); taken daily
5g Creatine Monohydrate powder + 150mg Resistant dextrin capsules (administered as 1 capsule, containing 150mg/capsule) (placebo); taken daily
Find a Clinic Near You
Who Is Running the Clinical Trial?
Applied Science & Performance Institute
Lead Sponsor
Citations
Creatine in Health and Disease - PMC
Several studies have found that creatine supplementation attenuates mental fatigue [27,28,127] and/or can improve cognition, executive function, and/or memory. ...
Creatine for Exercise and Sports Performance, with Recovery ...
The outcomes of the review indicated an overall effect size of 0.336 and 0.297 for the strength increases in the back squat and leg press exercises, ...
Safety And Efficacy Of Creatine Monohydrate ...
Some studies indicate that creatine supplementation can improve the performance of sprints that occur during or following endurance exercise. New data indicate ...
Single dose creatine improves cognitive performance and ...
Our outcomes show that administering a high single dose of creatine can partially reverse metabolic alterations and fatigue-related cognitive ...
The effects of creatine supplementation on cognitive ...
These results indicate that creatine supplementation has a significant positive impact on memory function, effectively improving memory ...
Effect of Creatine Monohydrate on SpatialWorking Memory ...
Creatine supplementation has been shown to have a beneficial effect on muscle growth, strength, and recovery as well as improved exercise ...
Effect of High-Dose Creatine Therapy on Symptoms ...
In this follow-up study, we found that higher dosages of Cr (150 mg/kg daily) worsened the main clinical features of exercise intolerance in McArdle disease.
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healthydirections.com
healthydirections.com/articles/general-health/creatine?srsltid=AU7gw4VyFVpxnWXfn4PWIPT_2OHbUZm0rG6Ds_80_vDjYJRD9C0vA9XzCreatine & Cognitive Performance
Creatine is a proven supplement for exercise performance, especially for strength training. But can it help with cognitive performance too?
Creatine and Nutrition: What 30 Years of Research Actually ...
Comprehensive creatine review: dosing protocols, food sources, proven benefits, safety data, and myth debunking based on 30 years of ...
Study Details | NCT06483321 | Effect of Creatine ...
The primary objective of this study is to investigate the effect of creatine monohydrate supplementation on body composition, physical performance, and muscle ...
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