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Movie-Watching fMRI for Brain Tumor

YT
LR
Overseen ByLaura Rigolo
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Brigham and Women's Hospital
Disqualifiers: Pregnancy, MRI contraindications, others
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This research will compare a new type of functional MRI (fMRI) called naturalistic viewing (also called movie watching) to standard clinical fMRI techniques. Standard clinical fMRI currently uses multiple tasks such as reading and responding to words or sentences to determine which areas of the brain are responsible for language. Surgeons can use this information to help plan brain surgeries. This research will help determine if the movie-watching fMRI is equivalent or better than the standard task-based fMRI. If so, it could be useful for planning patients' surgeries in the future, without the need for multiple tasks.

Who Is on the Research Team?

YT

Yanmei Tie, PhD

Principal Investigator

Brigham and Women's Hospital

Are You a Good Fit for This Trial?

This trial is for adults aged 21-70 with a known or suspected brain tumor (glioma) who are scheduled for a clinical fMRI before surgery at Brigham and Women's Hospital. Participants must speak English, be able to have an MRI, and not be pregnant.

Inclusion Criteria

English speaking
Patients with clinical fMRI scheduled or pending scheduling for presurgical planning at BWH ordered by a BWH clinician
Willing to participate in the additional study scan and neuropsychological assessment visit
See 4 more

Exclusion Criteria

Contraindications to MRI as determined by radiology staff during standard clinical scan screening
Subjects who self-report pregnancy or have positive pregnancy test results
I am not pregnant or possibly pregnant if I am a woman under 55 (or under 45 with recent periods).

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Neuroimaging Assessment

Participants undergo functional MRI (fMRI) using naturalistic viewing and standard task-based techniques to map brain function

Up to 6 months
Multiple visits for fMRI sessions

Follow-up

Participants are monitored for language localization and lateralization outcomes up to 6 months after brain surgery

6 months

What Are the Treatments Tested in This Trial?

Trial Overview

The study compares a new movie-watching fMRI method to the standard task-based fMRI in mapping language areas of the brain. Both scans help surgeons plan safer brain surgeries. Participants also complete neuropsychological assessments.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: FMRI and Neuropsychological AssessmentsExperimental Treatment2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Brigham and Women's Hospital

Lead Sponsor

Trials
1,694
Recruited
14,790,000+

National Institute on Deafness and Other Communication Disorders (NIDCD)

Collaborator

Trials
377
Recruited
190,000+

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