Imaging Techniques for Age-Related Macular Degeneration
What You Need to Know Before You Apply
What is the purpose of this trial?
This research sub-study is to evaluate if combining images from Optical Coherence Tomography (OCT) scans with Adaptive Optics Scanning Light Ophthalmoscopy (AOSLO) and Microperimetry (MP) could show a link between structural changes in the back of the eye and vision. 10 participants that were enrolled in the COmparison of Clarus and Optos Ultrawide Field Imaging Systems for Geographic Atrophy study \[NCT05961332\] will be approached to enroll. Participants may complete OCT imaging and initial assessments during an initial visit and may return for additional procedures, including microperimetry and AOSLO imaging, within a window of up to 4 weeks.
Who Is on the Research Team?
Amitha Domalpally, MD, PhD
Principal Investigator
University of Wisconsin, Madison
Are You a Good Fit for This Trial?
This trial is for people already enrolled in a related study on geographic atrophy, a form of age-related macular degeneration. Participants should be able to undergo eye imaging tests and follow-up visits within about 4 weeks.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Imaging Procedures
Participants undergo imaging procedures including OCT, microperimetry, and AOSLO to evaluate photoreceptor damage and correlate structural changes with vision.
Follow-up
Participants are monitored for safety and effectiveness after imaging procedures
What Are the Treatments Tested in This Trial?
Trial Overview
The study is testing whether combining three advanced eye imaging techniques—OCT, AOSLO, and microperimetry—can better link changes seen in the back of the eye with vision loss in macular degeneration.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Imaging procedures may be completed during a single study visit or across two study visits based on participant availability and operational workflow. When procedures occur across two visits, OCT imaging will be performed first to allow WRC review prior to scheduling microperimetry and AOSLO imaging. If all procedures are completed during a single visit, the total visit time is approximately 5-6 hours. If a second study visit is needed, only the remaining study procedures will be completed, so the second visit will be shorter since the initial ophthalmic procedures have already been performed.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Wisconsin, Madison
Lead Sponsor
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