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Psychosocial Intervention for Schizophrenia Prevention

YM
LE
Overseen ByL. Elliot Hong, MD
Age: < 65
Sex: Any
Trial Phase: Academic
Sponsor: The University of Texas Health Science Center, Houston
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to compare the effect of a brief family-based psychosocial intervention that addresses modifiable SSD risk factors on persistent and distressing psychotic-like experiences in children and young adults with a family history of SSD and high versus low baseline SSD-like brain patterns

Who Is on the Research Team?

YM

Yizhou Ma, PhD

Principal Investigator

The University of Texas Health Science Center, Houston

Are You a Good Fit for This Trial?

This trial is for children and young adults who have a family history of schizophrenia spectrum disorders (SSD) and show certain brain patterns linked to SSD risk. Participants should not have conditions that would prevent them from joining or completing the study.

Inclusion Criteria

I have been psychiatrically stable with no major medication changes in the past 4 weeks.
Family history of SSD defined as first-degree, second-degree, or other biological relatives with SSD or related severe mental illnesses equivalent to at least 25% genetic sharing confirmed by medical record review, parent/legal guardian report, and structured interview
Screening positive for two or more risk factors targeted by the intervention
See 1 more

Exclusion Criteria

Not able to undergo MRI
Current or past history of psychotic disorders or clinical high risk for psychosis (CHR-p) per study interview
I am not able to give my consent or permission for treatment.
See 4 more

What Are the Treatments Tested in This Trial?

Interventions

  • Psychosocial intervention

Trial Overview

The study tests whether a short, family-based psychosocial program can help reduce ongoing distressing psychotic-like experiences in at-risk youth compared to usual care. The focus is on prevention using support and education.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Psychosocial intervention groupExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

The University of Texas Health Science Center, Houston

Lead Sponsor

Trials
974
Recruited
361,000+

National Institutes of Health (NIH)

Collaborator

Trials
2,896
Recruited
8,053,000+

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