Cognitive Training for Mild Cognitive Impairment
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores a cognitive training program for individuals with Mild Cognitive Impairment (MCI). The researchers aim to determine if a shorter, five-week training can match the effectiveness of an eight-week program in enhancing memory, thinking skills, quality of life, mood, and reducing caregiver stress. Participants will complete memory and thinking tests, attend weekly cognitive training sessions, and retake tests after the training concludes. Ideal participants have MCI, can speak English, are willing to commit to the study, and have someone close, like a family member, to assist with the initial and post-training testing. As an unphased trial, this study offers participants the chance to contribute to valuable research that could improve cognitive training methods for MCI.
Do I need to stop my current medications to join the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that this cognitive training is safe for people with Mild Cognitive Impairment?
Research has shown that Motivationally Enhanced Compensatory Cognitive Training (ME-CCT) is generally safe for individuals with mild memory and thinking problems, often referred to as Mild Cognitive Impairment (MCI). Studies have found that this training is well-tolerated, with no serious side effects reported in past research on similar programs.
In trials of both short and full versions of this training, participants did not report major safety concerns. The available safety data suggests that both the five-week and eight-week training programs are safe. These programs do not involve medication or invasive procedures, which typically reduces the risk of side effects. Instead, they focus on exercises and activities designed to improve thinking skills.12345Why are researchers excited about this trial?
Researchers are excited about Brief Motivationally Enhanced Compensatory Cognitive Training for Mild Cognitive Impairment (bME-CCT-MCI) and Motivationally Enhanced Compensatory Cognitive Training for Mild Cognitive Impairment (ME-CCT-MCI) because they offer innovative approaches to help manage mild cognitive impairment. Unlike traditional medications that primarily focus on slowing cognitive decline, these treatments involve structured cognitive training sessions aimed at improving cognitive skills and compensatory strategies. The bME-CCT-MCI is a brief, five-week program, while the ME-CCT-MCI extends to eight weeks, providing varied intensity levels to suit different patient needs. By emphasizing motivational enhancement, these approaches aim to boost engagement and effectiveness, potentially leading to better outcomes in cognitive function and quality of life.
What evidence suggests that this trial's cognitive training interventions could be effective for Mild Cognitive Impairment?
Research has shown that brain exercises can improve memory and thinking skills in people with Mild Cognitive Impairment (MCI). Studies have found that these therapies enhance specific mental abilities and assist with daily tasks. Participants have reported high satisfaction and better problem-solving skills with a program called Motivationally Enhanced Compensatory Cognitive Training (ME-CCT). Additionally, brain exercises have been linked to improved mood and quality of life. In this trial, participants will join either a five-week or an eight-week cognitive training program. These findings suggest that both training durations might effectively boost mental abilities and daily living for those with MCI.12346
Who Is on the Research Team?
Cameron K Perrin, M.S.
Principal Investigator
University of Florida
Joseph M Gullett, Ph.D.
Principal Investigator
University of Florida
Are You a Good Fit for This Trial?
This trial is for people over 65 with Mild Cognitive Impairment (MCI) who can commit to the study, speak English, and have a partner to help with testing. They should have an MCI diagnosis or specific scores on cognitive tests.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants attend weekly two-hour group cognitive training sessions for five or eight weeks
Post-Treatment Assessment
Participants redo in-person questionnaires and tests of memory and thinking immediately after completing the training
Follow-up
Participants are monitored for safety and effectiveness three months after completing the training
What Are the Treatments Tested in This Trial?
Interventions
- Brief Motivationally Enhanced Compensatory Cognitive Training for Mild Cognitive Impairment (bME-CCT-MCI)
- Motivationally Enhanced Compensatory Cognitive Training for Mild Cognitive Impairment (ME-CCT-MCI)
Trial Overview
The trial is testing if five weeks of group cognitive training sessions are as effective as eight weeks in improving memory, quality of life, daily functioning, mood, and reducing caregiver burden for those with MCI.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Participants in this group will attend the brief, five-week version of cognitive training
Participants in this group will attend the full, eight-week version of cognitive training
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Florida
Lead Sponsor
Citations
Brief Cognitive Training for Mild Cognitive Impairment
The goal of this clinical trial is to develop a five-week cognitive training intervention for people with Mild Cognitive Impairment (MCI).
Feasibility of Motivationally Enhanced Compensatory ...
Mild Cognitive Impairment (MCI) increases risk for functional decline and dementia, yet effective interventions for older adults remain limited.
Cognitive Rehabilitation for Veterans With MDD-related ...
The primary objective of this pilot clinical trial is to evaluate the feasibility and acceptability of a manualized, 8-week, Compensatory Cognitive Training ( ...
4.
cogtale.org
cogtale.org/wp-content/uploads/2023/05/Motivationally-Enhanced-Compensatory-Cognitive-Training-for-MCI-2.pdfMotivationally Enhanced Compensatory Cognitive Training ...
How common is MCI? o Up to 30% or more of older adults may have mild cognitive impairment. o More common as individuals get older. o Younger adults may also ...
a review of social, cognitive, and physical stimulation ...
Meta-analyses suggest that cognitive training can lead to domain-specific improvements and may generalize to everyday functioning, although ...
Compensatory and Lifestyle-Based Brain Health Program ...
Our pilot study demonstrates preliminary feasibility of a cognitive compensatory and lifestyle-based brain health program.
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