Diet, Exercise, and Meditation for Parkinson's Disease

This trial explores how a mix of exercise, meditation, and diet, known as IMPACT 360, can benefit people with Parkinson's disease. Participants will either start this program immediately or begin after a 6-month period of continuing their usual routines. The researchers aim to assess how these lifestyle changes affect health indicators related to Parkinson's. Individuals diagnosed with Parkinson's who have access to a smartphone and computer may be suitable for this study. As a Phase 2 trial, this research focuses on measuring the treatment's effectiveness in an initial, smaller group, offering participants a chance to contribute to important early findings.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Previous studies have shown parts of the IMPACT 360 treatment to be safe. Research consistently shows that exercise is safe and offers health benefits, improving fitness and lowering the risk of many diseases without causing major problems.

Mindfulness meditation, another part of the treatment, has helped with both movement and non-movement symptoms in Parkinson's patients, with few negative effects reported. Studies suggest mindfulness can reduce anxiety and improve quality of life without major safety concerns.

Lastly, dietary changes, especially those rich in fruits, vegetables, whole grains, and fish, are generally safe and beneficial. Diets like the Mediterranean diet have been linked to better outcomes for Parkinson's patients.

Unlike standard treatments for Parkinson's disease, which often involve medications like Levodopa to manage symptoms, the IMPACT 360 approach combines exercise, diet, and mindfulness as a holistic intervention. Researchers are excited about this trial because it explores non-pharmacological strategies that may enhance quality of life and potentially slow disease progression. By incorporating physical activity and mindfulness practices, this method aims to address both the physical and mental aspects of Parkinson's, offering a comprehensive alternative that could reduce reliance on medication.

This trial will compare an intervention group with a waitlist group. Research has shown that exercise can improve movement and overall health in people with Parkinson's disease. Intense exercise may protect brain cells that produce dopamine, a chemical crucial for movement. Studies suggest that a healthy diet, such as the Mediterranean diet rich in fruits, vegetables, and fish, can lessen symptoms and slow disease progression. Mindfulness meditation can reduce stress, anxiety, and depression in individuals with Parkinson's. Participants in the intervention group will engage in exercise, diet, and mindfulness practices, which together might offer a comprehensive approach to managing the disease.¹²⁶⁷⁸