82 Participants NeededMy employer runs this trial

Avocado Meal Plan for Prediabetes

(FAM Trial)

CP
IE
Overseen ByIndika Edirisinghe, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether eating avocados daily can help manage triglycerides (a type of fat in the blood) and blood sugar levels in people with prediabetes and insulin resistance. Participants will follow either an avocado meal plan or a control plan without avocados, which will constitute most of their daily food intake. This trial may suit individuals with prediabetes who struggle with insulin resistance and are willing to incorporate avocado-based meals into their daily diet. As an unphased trial, it offers a unique opportunity to contribute to understanding dietary impacts on health.

What prior data suggests that the avocado meal plan is safe for people with prediabetes?

Research has shown that eating avocados is generally safe for most people, including those with prediabetes. Studies have found that regularly consuming avocados can lead to healthier eating habits and might help control blood sugar. For example, one study found that eating avocados every day for 12 weeks did not significantly change blood sugar levels. Another study suggested that avocados could help lower blood sugar and insulin levels in some people.

Overall, evidence suggests that adding avocados to meals is well-tolerated. These studies have reported no major side effects, and avocados are often recommended as part of a healthy diet for people with prediabetes.12345

Why are researchers excited about this trial?

Unlike the standard prediabetes treatments, which often include medications like Metformin or lifestyle changes focusing on exercise and general diet adjustments, the avocado meal plan takes a unique approach by integrating avocados directly into the diet. This treatment is distinctive because it specifically includes two meals and a snack daily that feature avocados, covering 80% of daily calorie needs. Avocados are rich in healthy fats and fiber, which can help stabilize blood sugar levels. Researchers are excited about this plan because it could offer a natural, food-based strategy to manage prediabetes, potentially enhancing metabolic health without medication.

What evidence suggests that the avocado meal plan might be an effective treatment for prediabetes?

Research has shown that eating avocados regularly can help control blood sugar levels. Studies have found that daily avocado consumption can lead to better blood sugar management, lower fasting insulin levels, and improved HbA1c, a measure of average blood sugar over time. One study discovered that adding avocado to meals can reduce the rise in blood sugar and insulin after eating. Avocados are also linked to a healthier diet and may help lower certain heart disease risk factors. For people with insulin resistance, avocados might make meals more satisfying and aid in weight management. In this trial, participants will follow an avocado meal plan, which includes two meals and a snack per day with avocado, or a control meal plan without avocado, to assess the impact on prediabetes management.12467

Who Is on the Research Team?

BB

Britt Burton-Freeman, PhD

Principal Investigator

Food Sci and Nut Programs

Are You a Good Fit for This Trial?

This trial is for adults with prediabetes or insulin resistance who want to help researchers understand how diet affects blood sugar and fat levels. People with certain health conditions or on specific medications may not be able to join.

Inclusion Criteria

Fasting triglycerides (TG) >115 mg/dL
Able to come to the clinic up to 6 times during the study
Able to avoid/abstain from alcohol and vigorous physical activity for 24 hours prior to and during study visit
See 5 more

Exclusion Criteria

Not weight stable (+/-10 lbs in previous 2 months)
Known or suspected intolerance, allergies or hypersensitivity to study foods or interventions
Fasting blood sugar ≥125 mg/dL
See 17 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1 week
1 visit (in-person)

Pre-Study / Pre-Intervention

Participants receive detailed instructions on study procedures and are trained on dietary restrictions and diary recording

1 day
1 visit (in-person)

Treatment

Participants consume a diet with or without avocado for 4 weeks, with regular meal pickup visits

4 weeks
5 visits (in-person)

Follow-up

Participants are monitored for changes in triglyceride metabolism and other biomarkers

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Avocado meal plan

Trial Overview

The study compares the effects of a meal plan that includes avocados versus a standard meal plan, focusing on changes in blood sugar and triglyceride (fat) metabolism. Participants are randomly assigned to one of the two diets.

How Is the Trial Designed?

2

Treatment groups

Active Control

Placebo Group

Group I: Avocado meal planActive Control1 Intervention
Group II: Control meal planPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Clinical Nutrition Research Center, Illinois Institute of Technology

Lead Sponsor

Trials
55
Recruited
3,000+

Hass Avocado Board

Collaborator

Trials
13
Recruited
760+

Citations

Avocado Consumption for 12 Weeks and Cardiometabolic ...

Avocado intake was associated with a healthier dietary pattern and trends favoring improved glucose control and reduced biomarkers of cardiometabolic risk.

Daily avocado consumption: A tasteful way to lower blood ...

Study results showed that daily avocado intake for 12 weeks had beneficial effects on blood glucose. Furthermore, avocado intake was associated ...

Avocado Consumption, Abdominal Adiposity, and Oral ...

Daily consumption of 1 fresh Hass avocado changed abdominal adiposity distribution among females but did not facilitate improvements in peripheral insulin ...

Avocado and blood sugar: what the evidence shows and ...

Adding avocado can improve meal satisfaction and blunt glucose response in mixed meals. Blood Sugar Level That Is Dangerous Small trials show that including ...

Does an avocado a day keep the doctor away? ...

If you have diabetes, adding avocado to your diet may help you lose weight, lower cholesterol, and increase insulin sensitivity. Some health ...

Using the Avocado as an Evening Snack to Investigate ...

The data suggested that a healthy evening snack with fibers improves glucose tolerance and lowers inflammatory markers and increases satiety [2,3]. Avocado ...

Avocado Mango for Pre-diabetes (AVMa Trial)

Research shows that eating avocados and mangoes is generally safe. Studies have found that these fruits can help control blood sugar and improve insulin use,