Ketamine + Fentanyl + Midazolam for Sedation in Interventional Radiology

This trial tests whether some radiology procedures can use deep sedation instead of general anesthesia, which requires more staff and equipment and may cause side effects. The study combines ketamine, midazolam, and fentanyl for sedation. Researchers aim to determine if these procedures can be completed without switching to general anesthesia, while monitoring patient comfort and recovery time. This trial may suit individuals needing an interventional radiology procedure who have previously struggled with lighter sedation methods. As a Phase 1 trial, the research focuses on understanding how the treatment works in people, offering participants the opportunity to contribute to groundbreaking medical advancements.

The trial information does not specify if you need to stop taking your current medications. It's best to discuss this with the study team or your doctor.

Research has shown that using ketamine and midazolam together to calm patients during certain medical procedures is generally safe and effective. Studies have found that this combination helps relax patients and is usually well-tolerated, with rare occurrences of breathing or blood pressure issues.

One study found that interventional radiologists using ketamine and midazolam for sedation achieved safe and effective results without needing an anesthesia team. This reduces the need for more complex and resource-intensive general anesthesia. Another study noted that patients experienced less discomfort with this combination compared to fentanyl and midazolam.

Researchers are excited about this trial because it explores a new sedation technique using ketamine, midazolam, and fentanyl for interventional radiology procedures. Unlike traditional sedation methods that might rely more heavily on general anesthesia, this approach offers deep sedation while potentially minimizing the risks associated with full anesthesia. The unique combination of ketamine, which has both sedative and pain-relieving properties, with midazolam and fentanyl, aims to provide effective sedation with potentially quicker recovery times. This could be a game-changer for patients who haven't responded well to lighter sedation methods, making complex, image-guided procedures more accessible and comfortable.

This trial will evaluate ketamine, midazolam, and fentanyl for deep sedation in interventional radiology procedures. Studies have shown that ketamine combined with midazolam works well for deep sedation during certain medical procedures. Research indicates that this combination provides more comfort than fentanyl with midazolam. Medical staff have safely used ketamine and midazolam without a full anesthesiology team, and serious side effects are rare. This method is preferred by medical staff and helps keep patients calm and comfortable during procedures. Additionally, ketamine relieves pain, enhancing the overall patient experience.¹²³⁵⁶