Metyrapone for Autonomous Cortisol Secretion
What You Need to Know Before You Apply
What is the purpose of this trial?
single-center, randomized, double-blind, placebo-controlled Phase 2 study to evaluate safety and efficacy of overnight metyrapone in patients with MACS.
Who Is on the Research Team?
Irina Bancos, MD, MS
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
This trial is for adults (18+) diagnosed with mild autonomous cortisol secretion (MACS) and have benign adrenal tumors. Participants may also have obesity, high blood sugar, cholesterol issues, high blood pressure, or low bone density. They must be willing to follow study procedures.Inclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Metyrapone
Trial Overview
The study compares a single overnight dose of metyrapone tablets versus placebo in people with MACS. It is randomized and double-blind, meaning neither participants nor doctors know who gets which treatment.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Subjects in the Metyrapone arm will receive the study drug
Subjects in the placebo arm will receive a placebo in lieu of study drug
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
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