Prehabilitation Exercise Program for Frailty

VE
RS
Overseen ByRitika Sharma
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Alberta
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to determine if a special exercise program can help frail adults recover better from surgery. The program combines strength training with advice to "sit less, move more" to reduce complications and speed up recovery. Adults aged 50 or older who feel physically vulnerable or frail and are scheduled for elective surgery might be suitable candidates. Participants will either follow this new exercise plan or continue with standard care. The goal is to make recovery smoother and lessen the burden on healthcare.

As an unphased trial, this study offers a unique opportunity to contribute to innovative recovery strategies and potentially benefit from personalized exercise guidance.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that this prehabilitation exercise program is safe for frail patients?

Research has shown that exercise programs, like the one being studied, are generally safe for older adults. Strength training, in particular, has proven effective and safe for enhancing physical strength and mental health. Studies indicate that even minimal resistance training can help manage frailty without major risks.

Physical activity plays a crucial role in improving frailty in older adults. It not only builds muscle strength but also reduces the risk of falls and related health issues.

These studies do not report any severe side effects, suggesting that such exercise programs are well-tolerated. Therefore, the program is likely safe for frail individuals, but it remains important to follow healthcare providers' advice during participation.12345

Why are researchers excited about this trial?

Researchers are excited about this trial because it combines neuromuscular exercise with a "sit less, move more" approach to tackle frailty in older adults. Unlike traditional treatments that may focus solely on physical therapy, this program emphasizes both strength training and reducing sedentary behavior. The use of personalized coaching and a Fitbit activity monitor helps participants actively engage with their daily routines, making it easier to incorporate light-intensity activities throughout the day. This dual approach aims to improve overall mobility and independence, offering a comprehensive solution that goes beyond standard rehabilitation practices.

What evidence suggests that this prehabilitation exercise program is effective for frailty?

This trial will evaluate a combined neuromuscular exercise training and "sit less, move more" program for frailty. Research has shown that exercise can significantly help manage frailty. Studies have found that exercise improves muscle strength and balance in older adults, which are crucial for reducing frailty. Strength training, in particular, can lessen the severity of frailty and related issues like muscle loss. Programs encouraging people to "sit less, move more" can increase daily activity and lower health risks associated with excessive sitting. Evidence suggests that even small amounts of resistance training can effectively improve strength and overall health in frail older adults. Participants in this trial will receive either the experimental exercise program or standard care.26789

Who Is on the Research Team?

NR

Naheed Rajabali, MD

Principal Investigator

Alberta Health services

VE

Victor Ezeugwu, PhD

Principal Investigator

University of Alberta

Are You a Good Fit for This Trial?

This trial is for people aged 50 or older who are scheduled for elective surgery and have been identified as vulnerable or mildly/moderately frail based on a clinical scale. They must be able to walk, with or without aids. Those with unstable medical conditions that limit exercise tolerance cannot participate.

Inclusion Criteria

I can walk by myself or with help like a cane or walker.
I am scheduled for a planned surgery.
I am somewhat frail but not completely dependent on others for daily activities.
See 1 more

Exclusion Criteria

I have a condition like ME/CFS that makes it hard for me to exercise.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Prehabilitation

Participants undergo a 12-week prehabilitation program combining neuromuscular strength training and sedentary behavior intervention

12 weeks
24 sessions (in-person)

Surgery and Immediate Postoperative Care

Participants undergo elective surgery and receive immediate postoperative care

1-2 weeks

Follow-up

Participants are monitored for safety and effectiveness after surgery, including assessments of gait speed, physical activity, and other health metrics

12-24 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Combined neuromuscular exercise training and 'sit less, move more' program

Trial Overview

The study tests if a pre-surgery program combining strength training exercises and activities aimed at reducing sitting time can decrease complications, shorten hospital stays, and speed up recovery in patients undergoing elective surgery.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: ExperimentalExperimental Treatment1 Intervention
Group II: Standard of careActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Alberta

Lead Sponsor

Trials
957
Recruited
437,000+

Victor Ezeugwu

Lead Sponsor

Trials
1
Recruited
50+

Royal Alexandra Hospital

Collaborator

Trials
20
Recruited
9,300+

Citations

Mind–body training outperforms other physical activities in ...

In our analysis, Mind–body training significantly improved frailty (SMD = −0.71, 95% CI: −1.22 ~ −0.21) and QoL (SMD = 1.02, 95% CI: −0.43 ~ ...

Physical activity and exercise: Strategies to manage frailty

Exercise reduces age-related oxidative damage and chronic inflammation, e in muscle strength may lead to reduced pulmonary function, low physical performance, ...

a systematic review and Bayesian network meta-analysis

Exercise interventions can effectively improve muscle strength and balance function in pre-frail older adults, with elastic band exercise and ...

Chronic Effects of Different Intensities of Power Training on ...

PT performed at low-to-moderate intensities induces similar power gains compared to high-intensity PT (70–80% of 1RM) in older adults.

Benefits of Resistance Training in Early and Late Stages ...

Generally, exercise interventions can decrease the prevalence of frailty and sarcopenia and are also effective in reducing the severity of these syndromes

Heavy Strength Training in Older Adults - PMC

However, taken together, the data suggest that heavy‐very heavy strength training results in a lower cardiovascular risk than strength training ...

Low-volume resistance training: a feasible, cost-effective ...

Our results indicate that even a low-volume resistance training program can yield meaningful benefits for managing frailty, sarcopenia and fall prevalence.

Growing Stronger - Strength Training for Older Adults

Feeling physically strong also promotes mental and emotional health. Strength training exercises are easy to learn, and have been proven safe and effective ...

Mind-body exercise best reduces frailty and boosts quality ...

Overall, mind-body training was considered to be 81% more effective in ameliorating frailty in older adults than all other interventions. Mind- ...