Ocular Light Exposure for Circadian Rhythm and Sleep

(SCOPE Trial)

This trial aims to explore how light exposure affects sleep, body clocks (circadian rhythms), and related hormones. Participants will wear a device to track sleep, complete health surveys, and undergo eye examinations. They will also measure pupil reactions to light at the hospital. Some participants might collect saliva at home to assess hormonal responses to light. This trial is open to individuals who are medically stable, have not undergone eye surgery, and can read and understand English well. As an unphased trial, this study offers a unique opportunity to contribute to scientific understanding of light's impact on health.

Studies have shown that light therapy, using a light box like the one in this trial, is generally safe. Research indicates it is widely used for treating sleep and mood issues, such as sleep disorders related to body clock changes, with few side effects. Minor issues might include slight eye strain or headache, but these are rare.

Most treatments for circadian rhythm and sleep disorders focus on medications like melatonin supplements or sleep aids. However, this new approach of using ocular light exposure from a portable light box is unique because it directly targets the body's natural light response system. Researchers are excited about this technique because it offers a non-invasive way to potentially reset and improve the body's internal clock through controlled light exposure. This method could provide a more natural, side-effect-free alternative to traditional medications, with the possibility of delivering quick and noticeable improvements in sleep patterns.

This trial will investigate the effects of ocular light exposure from a portable light box on circadian rhythm and sleep. Studies have shown that light therapy effectively addresses various sleep and body clock issues. For instance, morning light exposure can increase alertness and focus early in the day. Research also indicates that light therapy can help individuals fall asleep earlier and reduce sleep problems. Bright light therapy often treats delayed sleep phase syndrome, characterized by sleeping and waking later than usual. Additionally, light therapy can assist with insomnia, jet lag, and seasonal affective disorder by regulating sleep patterns. Overall, these findings suggest that light exposure can be a valuable tool for improving sleep and adjusting the body clock.⁴⁵⁶⁷⁸