Inhaled Cannabis for Cannabis Use

This trial explores how inhaling cannabis (THC), whether smoked or vaporized, affects lung health and breath markers compared to smoking a tobacco cigarette. Researchers aim to understand the differences in how these substances impact the lungs. The trial involves three groups: one using tobacco cigarettes, one using vaporized cannabis, and one using smoked cannabis. Ideal candidates are current recreational cannabis users who have recently smoked or vaporized cannabis and tobacco and are not seeking treatment for substance use. As an Early Phase 1 trial, this research focuses on understanding cannabis's effects on lung health, offering participants a chance to contribute to groundbreaking insights.

A previous study found that using vaporized cannabis poses less risk for lung damage compared to smoking it. Vaporizing avoids the harmful chemicals from burning, which can irritate the lungs and cause other problems. However, concerns remain about possible mental health effects, such as anxiety or depression.

Research has shown that smoking cannabis can cause short-term issues like sleepiness, slower reaction times, and coordination problems. It can also affect the lungs and increase the risk of heart problems. High doses might lead to anxiety and a rapid heartbeat.

Researchers are excited about these treatments because they explore new ways to utilize cannabis for those who use cannabis regularly. Unlike traditional methods which typically focus on cessation or reduction through behavioral therapies or pharmaceutical aids, this trial investigates the impact of different forms of cannabis consumption, including vaporized and smoked THC. These methods are unique because they directly study the effects of cannabis itself rather than substituting it with other treatments. By comparing vaporized cannabis, smoked cannabis, and tobacco cigarettes, researchers aim to better understand the role and potential benefits or drawbacks of cannabis as part of a harm reduction strategy for cannabis users. This could pave the way for more tailored and effective approaches to managing cannabis use.

This trial will compare different methods of cannabis use, including vaporized and combustible cannabis, with tobacco cigarettes. Studies have shown that vaporizing cannabis can produce stronger effects than smoking it. For instance, individuals who used a vaporizer with a 25-milligram dose of THC experienced more intense effects. Conversely, research suggests that smoking cannabis can affect motivation and reduce tobacco cravings. Observational studies indicate that combining cannabis and tobacco might lower tobacco cravings by 35%. While evidence points to some immediate effects from cannabis use, it's important to note that many users might develop a cannabis use disorder, impacting their overall health.⁶⁷⁸⁹¹⁰