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10 Participants NeededMy employer runs this trial

[18F]-FAPI-74 for Tuberculosis

MA
ES
Overseen ByErin Schubert
Age: 18+
Sex: Any
Trial Phase: Phase < 1
Sponsor: University of Pennsylvania
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This is an early phase study in patients with Tuberculosis (TB) to evaluate Fibroblast Activating Protein (FAP) activation as a marker of fibrosis. The Investigators propose to use FAP PET/CT to define the extent and location of FAP signals in lungs of TB patients early in TB treatment and after TB cure. These timepoints are chosen as they could be utilized to deliver treatments designed to prevent, predict, or treat Post-transplant Lymphoproliferative Disorder (PTLD). The overarching hypothesis is that greater FAP signals in lungs of adult TB patients are associated with greater imaging manifestations of PTLD after cure.

Who Is on the Research Team?

MA

Mark A Sellmyer, MD

Principal Investigator

UPENN, Gerd Muehllehner Associate Professor of Radiology

Are You a Good Fit for This Trial?

This trial is for adults diagnosed with tuberculosis (TB) in the lungs. Participants should be starting TB treatment or have recently completed it. People who are pregnant, breastfeeding, or unable to undergo PET/CT scans may not be eligible.

Inclusion Criteria

Have a Timika CXR score indicating cavitary disease
Be able and willing to provide written informed consent to participate in the study
I am 21 years old or older.
See 3 more

Exclusion Criteria

Women of childbearing potential may not be pregnant or breast-feeding; a negative pregnancy test required before [F-18]-FAPI-74 injection
Inability to tolerate imaging procedures in the opinion of an investigator or treating physician
Any current medical condition, illness, or disorder considered by a physician investigator to compromise participant safety or successful study participation
See 4 more

What Are the Treatments Tested in This Trial?

Interventions

  • [18F]-FAPI-74

Trial Overview

The study uses a special scan called [18F]-FAPI-74 PET/CT to look for signs of lung scarring and inflammation in TB patients at the start of treatment and after they are cured. The goal is to see if these scans can predict future lung problems.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Pulmonary Tuberculosis CohortExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Pennsylvania

Lead Sponsor

Trials
2,118
Recruited
45,270,000+

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