Virtual Reality for Depression

(VR-KET Trial)

This trial explores whether virtual reality (VR) can enhance the comfort and effectiveness of ketamine/esketamine treatments for people with depression. Participants will wear VR goggles and noise-canceling headphones to create a relaxing environment during treatments. This trial suits those already receiving ketamine/esketamine treatment for depression and continuing with maintenance sessions. However, individuals with significant hearing or vision issues, or those who struggle with English, cannot join. As an unphased trial, this study offers a unique opportunity to enhance the treatment experience with innovative VR technology.

The trial does not specify if you need to stop taking your current medications. However, since it involves ketamine/esketamine treatment, you should discuss your current medications with the study team to ensure there are no interactions.

Research has shown that virtual reality (VR) therapy is generally safe for treating mental health issues. Some studies indicate it can help reduce anxiety and improve mood with few side effects. For instance, VR therapy effectively treated specific fears, with success rates between 60% and 90%. These studies did not report any major negative effects. Additionally, VR therapy has been used to help people with depression feel better, without any serious safety concerns.

Virtual Reality is unique because it offers a new way to treat depression by immersing patients in simulated environments, potentially providing therapeutic benefits without medication. Unlike traditional treatments like antidepressants or psychotherapy, Virtual Reality can offer a more engaging and interactive experience that might help patients develop coping skills in a controlled yet dynamic setting. Researchers are excited about this approach because it opens up possibilities for personalized therapy sessions that can be tailored to individual needs, possibly leading to quicker and more sustainable improvements in mental health.

Research has shown that virtual reality (VR) can improve mood in people with depression. In one study, a VR game lifted the spirits of young participants. Another study found that VR therapy reduced depression over time, similar to traditional treatments. Additionally, a VR meditation program was linked to lower levels of depression and anxiety. This trial will explore the effects of VR therapy on depression, building on findings that suggest VR might enhance the effects of treatments like ketamine for depression.¹²⁶⁷⁸