Auditory Feedback for Work of Breathing

TD
Overseen ByTimothy D Mickleborough, PhD
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial investigates whether altering the sounds heard during breathing can influence perceptions of breathing and cognitive performance. It targets individuals who frequently encounter challenging breathing conditions, such as those using specialized breathing equipment in high-pressure environments. Participants will experience various sound settings—ambient noise, music, and enhanced breathing sounds (increased auditory feedback)—to assess their impact on perception and mental performance. Ideal candidates are physically active individuals who engage in intense exercise for at least 120 minutes a week and have no history of smoking or respiratory issues like asthma. As an unphased trial, this study provides a unique opportunity to contribute to innovative research without the constraints of traditional clinical trial phases.

Will I have to stop taking my current medications?

Yes, you will need to stop taking certain medications. The trial excludes participants who take selective serotonin reuptake inhibitors, stimulant medication, antibiotics, and those who chronically consume pain medication like Aleve or Tylenol.

What prior data suggests that this auditory feedback method is safe for cognitive performance?

Previous studies have shown that increased breathing noises are safe for people. Research indicates that devices providing sound feedback do not cause major negative effects. For example, one study found that participants felt more comfortable using a sound feedback device, possibly due to reduced stress or anxiety. Another study found that these sounds did not affect participants' physical performance, indicating that the sound feedback was well-tolerated. Overall, evidence suggests that sound feedback is safe and does not cause major problems.12345

Why are researchers excited about this trial?

Researchers are excited about this trial because it explores how different auditory feedback methods can impact the effort needed for breathing. Unlike standard treatments that might focus on medications or physical interventions, this approach uses sound—like ambient noise, music, and increased ventilation feedback—to potentially make breathing easier. The trial aims to uncover which auditory condition best supports respiratory function, offering a non-invasive, innovative way to assist those with breathing difficulties. By identifying the most effective auditory feedback, this research could pave the way for new therapeutic strategies that enhance breathing efficiency without the need for drugs or equipment.

What evidence suggests that increased auditory feedback is effective for reducing work of breathing?

Research has shown that changing the sounds of breathing, known as altered auditory feedback (AAF), can affect how the brain perceives and controls breathing. Studies have found that AAF can make breathing feel easier by modifying these sounds. This trial will explore different auditory conditions, including increased auditory feedback, to assess their impact on breathing perception. This method resembles how AAF aids people with speech problems, like stuttering, by altering what they hear to improve their speech. In other areas, such as speaking, listening to feedback helps maintain steady movements by allowing real-time adjustments. These findings suggest that more auditory feedback could alter breathing perception and might enhance cognitive skills during challenging breathing situations.25678

Are You a Good Fit for This Trial?

This trial is for healthy adults aged 18-40 who speak English, have a BMI of 35 or less, exercise intensely at least 2 hours per week, and have normal lung and cognitive function. People with high blood pressure, heart, lung, kidney, nerve or metabolic diseases, smokers, pregnant women, those on certain medications or with irregular periods cannot join.

Inclusion Criteria

English speaking and reading
I am between 18 and 40 years old.
Body mass index (BMI) ≤ 35 kg/m2
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Exclusion Criteria

Resting blood pressure of > 130mmHg systolic or 90 mmHg diastolic and/or resting pulse rate of > 100 bpm
History of smoking or recreational smoking, cardiovascular disease, renal disease, pulmonary disease (including asthma or exercise-induced asthma), neurological disease, and metabolic disease
My periods are irregular or I do not have periods.
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Timeline for a Trial Participant

Screening/Familiarization

Participants are screened for eligibility to participate in the trial

1 day
1 visit (in-person)

Experimental Visit

Participants complete three full-length breathing tasks under different auditory feedback conditions

1 day
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after the experimental visit

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Increased Auditory Feedback

Trial Overview

The study tests if changing how people hear their own breathing (using different types of noise and feedback) affects how hard breathing feels and impacts thinking skills when it's harder to breathe. Participants experience various sound conditions while their reactions are measured.

How Is the Trial Designed?

6

Treatment groups

Active Control

Group I: Ambient noise, then music distraction, then increased ventilation auditory feedbackActive Control3 Interventions
Group II: Ambient noise, then increased ventilation auditory feedback, then music distractionActive Control3 Interventions
Group III: Music distraction, then ambient noise, then increased ventilation auditory feedbackActive Control3 Interventions
Group IV: Increased ventilation auditory feedback, then ambient noise, then music distractionActive Control3 Interventions
Group V: Increased ventilation auditory feedback, then music distraction, then ambient noiseActive Control3 Interventions
Group VI: Music distraction, then increased ventilation auditory feedback, then ambient noiseActive Control3 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Indiana University

Lead Sponsor

Trials
1,063
Recruited
1,182,000+

United States Department of Defense

Collaborator

Trials
940
Recruited
339,000+

Citations

Auditory Feedback for Work of Breathing · Info for Participants

Participants will complete 3 full length breathing tasks, one under each auditory condition. The order of condition exposure will be assigned via randomization.

What Can Altered Auditory Feedback Paradigms Tell Us ...

The goal of this review article is to provide a summary of the progression of altered auditory feedback (AAF) as a method to understand the pathophysiology of ...

The Impact of Respiratory Exercises on Voice Outcomes

The results of this review suggest that the evidence to support using respiratory exercises to improve vocal function is specific to a patient's respiratory ...

Research Shows How Auditory Feedback Sharpens Speech

Our findings suggest that the brain continuously uses auditory feedback to stabilize speech movements, but not all articulators rely on it ...

5.

pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov/23280384/

Evaluation of auditory and visual feedback for airflow ...

To improve the intrasubject reliability, we evaluated the effect of auditory and visual feedback on subject performance when measuring aerodynamic parameters ...

Effect of a Real-Time Audio Ventilation Feedback Device on ...

The purpose of this study was to evaluate the effect of real-time audio ventilation feedback on the survival of patients with an ...

Evaluating Auditory Feedback for Accurate Compression ...

This study demonstrated no significant impact of auditory feedback on chest compression rates. Additionally, the potential for increased ...

Evaluation of auditory and visual feedback for airflow ... - PMC

Each feedback method significantly decreased the CV of RL compared to control trials (auditory: p=0.005; visual: p=0.008; combined: p<0.001). Auditory (p=0.011) ...