High-Protein Diet + Resistance Training for Weight Loss
What You Need to Know Before You Apply
What is the purpose of this trial?
The primary objective of this study is to examine the effects of a high-protein diet (HP) paired with resistance training (RT) compared with a HP diet alone, on skeletal muscle mass (SMM) volume of the (a) quadriceps and (b) rhomboids, and upper and lower body muscle strength in adults recently prescribed tirzepatide. The secondary objectives of this study are to compare changes in resting energy expenditure (REE), adaptive thermogenesis (AT), and body adiposity (SFV, VAT, and intramuscular FF) in the quadriceps and rhomboid muscles) between the high-protein diet with RT and the high-protein diet arms at 6 months.
Who Is on the Research Team?
Collin Popp, PhD
Principal Investigator
NYU Langone Health
Are You a Good Fit for This Trial?
This trial is for adults who have recently started taking tirzepatide (a medication for weight loss or diabetes) and want to improve muscle mass and strength. Participants should be able to follow a high-protein diet, with or without resistance training.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- High protein diet
- Resistance Training (RT) Programs
Trial Overview
The study compares two groups: one follows a high-protein diet plus resistance training, while the other follows only the high-protein diet. The main goal is to see which approach better improves muscle size and strength over six months.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
All participants will receive a HP dietary prescription targeting 2.5 g/kg fat-free mass (FFM)/day delivered by an RDN. Participants in the HP-RT arm will additionally complete supervised resistance training 2 days/week for 6 months under the guidance of a personal trainer/Certified Strength and Conditioning Specialist (CSCS).
All participants will receive a HP dietary prescription targeting 2.5 g/kg FFM/day delivered by an Registered Dietitian Nutritionist (RDN).
Find a Clinic Near You
Who Is Running the Clinical Trial?
NYU Langone Health
Lead Sponsor
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