100 Participants Needed

Incremental Vestibulo-Ocular Reflex Adaptation for Vestibular Hypofunction

Recruiting at 1 trial location
CR
HM
Overseen ByHannah M Morris
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to examine how vision issues affect treatment for individuals with vestibular hypofunction, a condition that impacts balance. Researchers are testing whether problems like blurry vision or difficulty focusing with both eyes alter the adaptation of the vestibulo-ocular reflex (VOR), which helps maintain steady vision during movement. Participants will include those with blurry vision or eye coordination issues, with or without vestibular problems. This trial may suit adults experiencing blurry vision without glasses or contact lenses or those struggling with visual coordination, especially if balance is also a concern. As an unphased trial, this study offers a unique opportunity to contribute to understanding vision and balance issues, potentially benefiting future treatments.

Will I have to stop taking my current medications?

The trial requires that you do not use medications that significantly affect vestibular function, like vestibular suppressants. If you are taking such medications, you may need to stop them to participate.

What prior data suggests that Incremental Vestibulo-Ocular Reflex Adaptation is safe?

Research shows that the Incremental Vestibulo-Ocular Reflex Adaptation (IVA) treatment is generally easy for people to handle. Earlier studies demonstrated promising results, such as improved eye movement in response to head motion, faster walking speed, and a lower risk of falling. These studies did not report any major side effects, suggesting that the treatment is safe for participants.

Although the specific study under consideration does not provide detailed safety information, IVA has been tested in several research settings without major safety concerns, which is reassuring. Discussing possible risks and benefits with the study team or a healthcare provider before joining a trial is always important.12345

Why are researchers excited about this trial?

Researchers are excited about the Incremental Vestibulo-Ocular Reflex Adaptation (IVA) because it tackles vestibular hypofunction in a novel way. Unlike standard treatments such as vestibular rehabilitation exercises, IVA focuses on adapting the vestibulo-ocular reflex (VOR) incrementally, which might result in more precise improvements in balance and vision coordination. This method is particularly intriguing because it could offer a tailored approach to individuals with specific visual and vestibular challenges, potentially leading to better outcomes than the more generalized current therapies.

What evidence suggests that Incremental Vestibulo-Ocular Reflex Adaptation could be effective for vestibular hypofunction?

Research shows that Incremental Vestibulo-Ocular Reflex Adaptation (IVA), which participants in this trial will receive, can enhance the coordination between the eyes and inner ear, known as the vestibulo-ocular reflex (VOR). This improvement can alleviate symptoms like dizziness in individuals with balance issues. Studies have found that IVA is more effective than traditional methods at enhancing VOR. It also aids in balance and reduces feelings of disability related to these issues. Participants often experience better control of head movements and less dizziness. Overall, IVA holds strong potential for improving symptoms related to balance problems.12678

Who Is on the Research Team?

CG

Colin Grove, PT, DPT, PhD

Principal Investigator

Emory University

Are You a Good Fit for This Trial?

This trial is for adults aged 18-89 who can consent to participate. It's suitable for those with poor uncorrected vision or binocular vision issues, with or without vestibular hypofunction (a balance disorder). Participants are divided into groups based on their visual and vestibular functions.

Inclusion Criteria

For All Participants (All Groups)
I am between 18 and 89 years old.
* Able to provide informed consent
See 7 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Experiment 1

Participants with abnormal uncorrected static visual acuity undergo VOR adaptation training with and without vision correction

2 visits (2-10 days apart)
2 visits (in-person)

Experiment 2

Participants with binocular vision abnormalities undergo VOR adaptation training in their best corrected visual state

2 visits (2-10 days apart)
2 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after training

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Incremental Vestibulo-Ocular Reflex Adaptation (IVA)

Trial Overview

The study tests how well people adapt their Vestibulo-Ocular Reflex (VOR), which helps maintain stable vision during head movements, using Incremental VOR Adaptation training. It compares the adaptation in individuals with different combinations of visual and vestibular impairments.

How Is the Trial Designed?

4

Treatment groups

Experimental Treatment

Group I: Group 4: Binocular Vision Abnormalities + Vestibular HypofunctionExperimental Treatment1 Intervention
Group II: Group 3: Binocular Vision Abnormalities (No Vestibular Hypofunction)Experimental Treatment1 Intervention
Group III: Group 2: Abnormal Uncorrected Static Visual Acuity + Vestibular HypofunctionExperimental Treatment1 Intervention
Group IV: Group 1: Abnormal Uncorrected Static Visual Acuity (No Vestibular Hypofunction)Experimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Emory University

Lead Sponsor

Trials
1,735
Recruited
2,605,000+

Citations

NCT07380256 | Visual Influences on Vestibular Adaptation

The goal of this study is to determine whether impaired static visual acuity or binocular vision abnormalities affect vestibulo-ocular ...

2.

pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov/34369452/

Comparison of Incremental Vestibulo-ocular Reflex ...

Discussion and conclusions: Our results suggest IVA improves VOR gain and reduces perception of disability more than conventional x1 training.

Incremental Vestibulo-Ocular Reflex Adaptation Enhances ...

Purpose/Hypothesis: Vestibular hypofunction affects 8% of adults and causes oscillopsia due to a weak vestibulo-ocular reflex (VOR).

Once-Daily Incremental Vestibular-Ocular Reflex Adaptation ...

Conclusions: Our results suggest incremental VOR adaptation sig- nificantly improves gain, gait with head rotation, balance during gait, and symptoms in ...

New advances regarding adaptation of the vestibulo- ...

For most subjects, VOR gain after ×2 training did improve, albeit by a much smaller amount than after incremental training; most subjects showed no change. [ ...

Incremental VOR Adaptation: Clinical Trial Results

In addition to improving the gain of the VOR, IVA improves walking velocity, reduces fall risk, and increases the ability to see clearly during ...

Incremental Vestibulo-ocular Reflex Adaptation as a Novel ...

The study aims to study the effects of a novel treatment for vestibular symptoms in people with multiple sclerosis. The main objective is to determine ...

Comparison of incremental vestibulo-ocular reflex ...

Primary outcome: vestibulo-ocular reflex gain. Secondary outcomes: compensatory saccades, dynamic visual acuity, static balance, gait, and subjective symptoms.