Hypochlorous Acid for Prosthetic Graft Infection

MC
Overseen ByMichael C Stacey, MBBS, DS, FRACS
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Hamilton Health Sciences Corporation
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This is a study of the use of an antibacterial solution, Hypochlorous acid, to prevent infection in vascular surgery bypass grafts. The solution will be used at the end of operations to insert a prosthetic vascular surgery bypass graft, to wash the wound and the vascular bypass graft before the wound is closed. The patients in this study will be undergoing surgery for problems with narrowed and or blocked arteries. The presence or absence of a graft infection will be followed for 12 months following the surgery. Prosthetic vascular graft infections have significant implications for patients with high rates of death and amputation, hence preventing them will have significant benefits for patients and the health care system.

Are You a Good Fit for This Trial?

This trial is for people who are having surgery to get a prosthetic vascular bypass graft due to narrowed or blocked arteries. Participants must be eligible for this type of surgery and able to follow up for 12 months after the operation.

Inclusion Criteria

I am 18 years old or older.
Able to provide informed consent in English
I am having surgery to place a prosthetic vascular graft in my abdomen or leg.

Exclusion Criteria

I am unable to give informed consent in English.
I am under 18 years old.
I am having open vascular surgery without a prosthetic graft in my abdomen or legs.

What Are the Treatments Tested in This Trial?

Interventions

  • Hypochlorous acid

Trial Overview

The study tests whether washing the surgical wound and new vascular graft with hypochlorous acid at the end of surgery can help prevent infections, compared to standard care. Patients will be monitored for infection over one year.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Hypochlorous acidExperimental Treatment1 Intervention
Group II: Standard of careActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Hamilton Health Sciences Corporation

Lead Sponsor

Trials
380
Recruited
345,000+

McMaster University

Collaborator

Trials
936
Recruited
2,630,000+