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Electronic Cigarette Settings for Vaping

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ZB
Overseen ByZachary Btizer, Ph. D.
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Milton S. Hershey Medical Center
Disqualifiers: Pregnancy, Respiratory diseases, Kidney, Liver, others
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This project seeks to determine how e-cigarette (EC) physical design features, including those that allow the user to manipulate the quality and quantity of aerosols, affect exposure and toxicity from oxidants and other aerosol constituents.

Who Is on the Research Team?

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Zachary Bitzer, Ph.D.

Principal Investigator

Penn State Hershey College of Medicine

Are You a Good Fit for This Trial?

This trial is for adults who use tobacco or e-cigarettes. Participants should be generally healthy and able to follow study instructions. People with certain health conditions, pregnant women, or those unable to safely participate may not be eligible.

Inclusion Criteria

No plan on quitting nicotine use over the course of the study
Able to read and write in English
Have access to email and a smartphone/computer that has reliable internet connection
See 4 more

Exclusion Criteria

I am currently pregnant, nursing, or trying to become pregnant.
Have immediate family or household members currently participating in this trial
Uncontrolled substance abuse or inpatient treatment for that condition in the past 6 months
See 2 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants use study e-cigarettes and e-liquids, with puffing behavior and biomarkers monitored

2 weeks
1 visit (in-person) after 2 weeks of at-home use

Laboratory Assessment

Participants' puffing behavior and biomarkers are assessed during a 5-minute laboratory session

5 minutes
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Trial Overview

The study tests how different settings on electronic cigarettes—specifically low vs high temperature and low vs high levels of propylene glycol—affect the body’s exposure to harmful substances from vaping.

How Is the Trial Designed?

4

Treatment groups

Experimental Treatment

Group I: Low Wattage/Low Propylene GlycolExperimental Treatment2 Interventions
Group II: Low Wattage/High Propylene GlycolExperimental Treatment2 Interventions
Group III: High Wattage/Low Propylene GlycolExperimental Treatment2 Interventions
Group IV: High Wattage/High Propylene GlycolExperimental Treatment2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Milton S. Hershey Medical Center

Lead Sponsor

Trials
515
Recruited
2,873,000+

National Institute on Drug Abuse (NIDA)

Collaborator

Trials
2,658
Recruited
3,409,000+

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