EMG vs AMG Devices for Surgery

(PEARL Trial)

Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Mayo Clinic
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to determine the best way to manage anesthesia during robotic or laparoscopic surgery by comparing two methods: acceleromyography (AMG) and electromyography (EMG). Both methods assist doctors in measuring the appropriate amount of muscle relaxant needed during surgery. Suitable candidates for this trial include individuals undergoing elective (non-emergency) robotic or laparoscopic surgery expected to last less than 5 hours, without certain nerve or muscle disorders. As an unphased trial, it offers participants the chance to contribute to medical knowledge and potentially enhance surgical outcomes.

Do I need to stop my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that these EMG and AMG devices are safe for surgery?

Research has shown that robotic-assisted surgeries, which use tools like AMG (a type of muscle monitoring), are generally safe for patients. These surgeries aim to improve outcomes and reduce surgery-related complications. Studies have found that robotic surgeries often result in fewer intraoperative complications compared to traditional methods.

For monitoring, EMG (another type of muscle monitoring) is often considered more reliable than AMG. EMG provides better readings and is less affected by patient movement, aiding in more effective anesthesia management, which is crucial for patient safety.

Overall, both AMG and EMG monitoring methods have been well-tolerated in surgeries, with no significant reports of problems directly linked to their use. This suggests that the treatments in this study are likely safe for patients.12345

Why are researchers excited about this trial?

Researchers are excited about this trial because it explores new ways to manage anesthesia during robotic and laparoscopic surgeries. Unlike traditional methods that typically use subjective assessments or general guidelines, this trial compares the precision of using EMG (electromyography) and AMG (acceleromyography) to monitor muscle block levels. EMG and AMG provide real-time, quantitative data to potentially enhance the accuracy of anesthesia management, which could lead to improved patient outcomes and safer surgical procedures.

What evidence suggests that EMG and AMG devices are effective for surgery?

This trial will compare acceleromyography (AMG) and electromyography (EMG) for managing anesthesia during robotic or laparoscopic surgeries. Research has shown that both AMG and EMG are useful in this context. In the AMG arm, anesthesiologists will manage anesthesia based on AMG values, allowing for more accurate monitoring of muscle relaxation and potentially improving patient outcomes. In the EMG arm, anesthesia will be managed based on EMG values, providing crucial information about nerve and muscle function during surgery to maintain the appropriate level of anesthesia. Both methods aim to enhance surgical safety and speed up recovery.12467

Who Is on the Research Team?

JR

Johnathan Renew

Principal Investigator

Mayo Clinic

Are You a Good Fit for This Trial?

This trial is for adults (18+) having planned robotic or laparoscopic surgery lasting less than 5 hours. People with kidney problems, nerve or muscle disorders, certain wrist injuries, or surgeries involving the arm can't join.

Inclusion Criteria

I am willing to join the study and give my informed consent.
I am scheduled for an elective laparoscopic or robotic surgery.
My planned surgery will take less than 5 hours.
See 1 more

Exclusion Criteria

I have chronic kidney disease with reduced kidney function.
Patients with disorders, such as stroke, carpal tunnel syndrome, broken wrist with nerve damage, Dupuytren contracture, or any similar wrist injury
Patients with systemic neuromuscular diseases such as myasthenia gravis
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Perioperative/Periprocedural

Participants undergo robotic- or laparoscopic-assisted surgery with neuromuscular block management using either EMG or AMG

1 day
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after surgery

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Robotic/Laparoscopic Surgery

Trial Overview

The study compares two devices—electromyography (EMG) and acceleromyography (AMG)—used to monitor muscle relaxation during surgery by measuring how much rocuronium (a muscle relaxant) patients need.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: AMGExperimental Treatment1 Intervention
Group II: EMGActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials
3,427
Recruited
3,221,000+

Citations

Anaesthetic management of robot-assisted laparoscopic surgery

Smaller surgical incisions, less discomfort, a shorter hospital stay, and speedier recovery are some of the possible benefits for patients; ...

Anesthesia management and patient outcomes in robotic ...

Robotic surgical techniques aimed to improve patient outcomes and satisfy patient outcomes while reducing surgical morbidity and mortality.

Perioperative outcomes and anesthetic challenges of robotic ...

This review aims to evaluate perioperative outcomes across four domains: intraoperative anesthetic management, postoperative recovery, pain control strategies, ...

Anesthesia for robot-assisted surgery: a review

This review discusses problems that may be encountered by an anesthesiologist performing anesthesia during robotic surgery.

5.

pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov/41311504/

Outcomes Comparing 19769 Patients Who Underwent ...

Results: Among 19,769 patients, robotic surgery was associated with shorter hospital stays (5.6 days vs 7.9 for laparoscopic and 11.2 for open, P < .0001), ...

Safety and Efficacy Outcomes of Robotic, Laparoscopic ... - PMC

Network analysis: Robotic surgery had a 70.7% probability of reducing intra-operative complications compared to laparoscopy (LPS) and a 99.2% ...

EMG vs. Subjective Monitoring: What the Data Tells Us

Learn how quantitative EMG monitoring outperforms subjective twitch assessments in reducing residual paralysis and improving patient ...