Overdose Prevention for Substance Use Disorder and Homelessness
(HOPE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
Homeless Overdose Prevention - Expansion (HOPE), tests implementation of overdose education and naloxone distribution (OEND), a program that targets homeless experienced Veterans at risk for overdose, including Veterans in community-based supportive housing. HOPE sites will receive a playbook that offers step-by-step instructions, tools, templates, and checklists tailorable to site needs; sites will also receive performance feedback about their performance relative to a standard or benchmark.
Who Is on the Research Team?
Amanda M. Midboe, PhD
Principal Investigator
VA Palo Alto Health Care System, Palo Alto, CA
Are You a Good Fit for This Trial?
This trial is for Veterans who are homeless or in supportive housing, enrolled in the HUD-VASH program, and at risk for opioid overdose based on specific VA data. Participants must be patients at a site taking part in this study.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Low-Intensity Implementation
The LI implementation approach includes providing sites with the HOPE Implementation Playbook and leading a monthly learning collaborative for 6 months.
High-Intensity Implementation
The HI approach includes creation of a novel clinical team, monthly overdose education and training, monthly audit and feedback, and technical assistance.
Follow-up
Participants are monitored for the maintenance of OEND as part of routine organizational practices and policies.
What Are the Treatments Tested in This Trial?
Interventions
- Homeless Overdose Prevention- Expansion (HOPE) - High Intensity
- Homeless Overdose Prevention- Expansion (HOPE) - Low Intensity
Trial Overview
The study compares two levels of support (low vs. high intensity) for an overdose education and naloxone distribution program called HOPE, aimed at helping homeless-experienced Veterans avoid opioid overdoses.
How Is the Trial Designed?
2
Treatment groups
Active Control
The LI implementation approach will include providing sites with the HOPE Implementation Playbook, including access to the associated resources (e.g., OEND note templates) on the HOPE SharePoint site. Investigators will begin with an initial training session with each site, and lead a monthly learning collaborative for 6 months. The LI phase will allow evaluation of the effect of a comprehensive playbook on uptake of OEND.
The HI approach will include: (1) creation of a novel clinical team (i.e., prescriber and HUD-VASH team) if not created under LI; (2) monthly overdose education and training delivered synchronously via Microsoft Teams; (3) monthly audit and feedback for each HUD-VASH team on progress toward providing OEND; and (4) technical assistance. Investigators hypothesize the HI implementation strategy will have a greater impact on RE-AIM outcomes.
Find a Clinic Near You
Who Is Running the Clinical Trial?
VA Office of Research and Development
Lead Sponsor
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