Practice Companion for Substance Use Disorder

Not yet recruiting at 4 trial locations
DF
SE
Overseen ByScott E Hadland, MD, MPH, MS
Age: < 65
Sex: Any
Trial Phase: Academic
Sponsor: Massachusetts General Hospital
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to create and test a guide, called the Practice Companion, to assist clinicians in supporting young people who use substances like opioids and cannabis. The guide will focus on overdose prevention and address mental health needs, as well as social factors like housing instability. Young people who have used drugs or alcohol in the past year and are receiving care at a participating site may be suitable candidates. The trial will evaluate the guide's usefulness and relevance for youth and their families. Findings will inform a larger future study on its effectiveness. As an unphased trial, this study offers participants the chance to contribute to developing a potentially impactful resource for youth substance use prevention.

What prior data suggests that this practice companion is safe for youth substance use care?

Research has shown that effective ways to help young people with substance use include harm reduction, preventing overdoses, and using medications to treat addiction. These methods have been tested in various settings and are generally well-received by patients. For instance, naloxone is widely accepted for preventing overdoses and has a strong safety record. Take-home drug testing strips also serve as a safe and effective tool for managing substance use.

The "practice companion" is being developed to tailor these approaches to young people's specific needs. Although no direct safety data exists for this "practice companion," it incorporates well-researched methods safely used in adults and now adapted for younger individuals.

Overall, these methods are considered safe, with very few reports of problems when used correctly. This suggests that the practice companion, based on these proven methods, is expected to be safe for participants.12345

Why are researchers excited about this trial?

Researchers are excited about the Practice Companion for Substance Use Disorder because it offers a holistic and youth-centered approach to treatment. Unlike standard options that may focus solely on stopping substance use, this method provides comprehensive care by addressing overdose prevention with tools like naloxone and take-home drug testing strips, alongside harm reduction education. It also supports mental health and substance use issues with non-stigmatizing, family-friendly guidance, tailored specifically for young people aged 14 to 24. This personalized and inclusive approach aims to meet individual needs more effectively than traditional treatments.

What evidence suggests that this practice companion is effective for substance use disorder?

Research has shown that community programs for substance use problems often work better than having no program at all. These programs help individuals reduce substance use, enhance mental health, and reconnect with their communities. This trial tests the Practice Companion as an experimental treatment. It incorporates research-based approaches such as harm reduction and overdose prevention, which have demonstrated slightly better results than standard care. These treatments are particularly important for young people, who often encounter unique challenges with substance use. Addressing both substance use and mental health together is crucial for long-term success.678910

Who Is on the Research Team?

DF

Danya Fast, PhD

Principal Investigator

University of British Columbia

SE

Scott E Hadland, MD, MPH, MS

Principal Investigator

Mass General Brigham for Children

NC

Nicholas Chadi, MD, MPH

Principal Investigator

Université de Montréal / CHU Sainte-Justine

Are You a Good Fit for This Trial?

This trial is for youth ages 14 to 24 who have used drugs or alcohol in the past year and are receiving care at a participating site. People with severe cognitive issues, those needing emergency medical help, or current members of the study's advisory board cannot join.

Inclusion Criteria

Uses drugs or alcohol in the past year
Receiving care at a participating study site
I am between 14 and 24 years old.

Exclusion Criteria

I do not have cognitive or intellectual disabilities that stop me from giving consent.
Any medical or psychiatric condition causing acute distress or requiring emergency evaluation
Current membership on a study Community Advisory Board

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Adaptation and Production

Interviews with youth, families, and clinicians to adapt care elements for youth, followed by production of the practice companion

6 months

Pilot Testing

Pilot testing of the practice companion with 60 youth across three sites, including qualitative exit interviews and surveys

18 months

Follow-up

Participants are monitored for acceptability and feasibility of the practice companion after receiving care

1-2 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Practice Companion

Trial Overview

The study is testing a written 'practice companion' guide that helps clinicians provide better substance use care tailored for young people. It covers harm reduction, overdose prevention, and mental health support. The guide will be piloted with about 60 youth across three locations.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Practice CompanionExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Massachusetts General Hospital

Lead Sponsor

Trials
3,066
Recruited
13,430,000+

University of British Columbia

Collaborator

Trials
1,506
Recruited
2,528,000+

Centre Hospitalier Universitaire Sainte-Justine (CHU-SJ) (University of Montreal)

Collaborator

Trials
1
Recruited
20+

National Institute on Drug Abuse (NIDA)

Collaborator

Trials
2,658
Recruited
3,409,000+

Boston Medical Center

Collaborator

Trials
410
Recruited
890,000+

Université de Montréal

Collaborator

Trials
223
Recruited
104,000+

Citations

Treatment Outcomes and Research

Reduced substance misuse · Improved physical and mental health · Stable housing and employment · Reconnection with family and community · Legal stability (e.g., no ...

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Substance Use Disorder Treatment Outcomes - PMC - NIH

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Group Therapy for Substance Use Disorders: A Survey ... - PMC

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Understanding the Impact of Community-Based Interventions ...

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Evidence-Based Practices Resource Center

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Substance use disorders: a comprehensive update of ... - PMC

The rates of SUDs randomized controlled trials (RCTs) reported 6‐month cessation rates of 20% when behavioral support was added to medications, ...

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Exploring Health Care Provider Knowledge and ...

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