Flicker Stimulation for Memory Loss

RS
Overseen ByRachael Seidler
Age: 65+
Sex: Any
Trial Phase: Academic
Sponsor: University of Florida
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether flicker stimulation can improve memory, movement, and mood in older adults who feel their memory has declined. Researchers aim to determine if this treatment, administered three times a week for three months, can slow brain changes often linked to Alzheimer’s. Participants will receive either flicker stimulation (a combination of light and sound) or a control treatment with white noise. Suitable candidates have noticed memory problems, have a family history of dementia, and can walk unassisted. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research that could lead to new ways to support brain health.

Do I need to stop my current medications to join the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that flicker stimulation is safe for older adults with Subjective Cognitive Decline?

Research has shown that flicker stimulation is generally safe for people. Small studies on 40-hertz sensory stimulation confirmed its safety, particularly for those with Alzheimer's disease. These studies found that participants handled the therapy well and it maintained a good safety record. Most participants continued the treatment without issues.

Participants in these studies reported no major side effects, suggesting flicker stimulation might be a safe option for those with memory loss or cognitive decline. Overall, these findings indicate that flicker stimulation could safely assist with memory problems.12345

Why are researchers excited about this trial?

Researchers are excited about flicker stimulation for memory loss because it offers a novel approach to enhancing cognitive function. Unlike traditional treatments, which often involve medications targeting neurotransmitters, flicker stimulation uses sensory visual and auditory signals to potentially boost brain activity and memory. This non-invasive method might engage the brain in a unique way, opening up possibilities for improving memory function without the side effects associated with pharmaceuticals.

What evidence suggests that flicker stimulation could be effective for memory loss?

Research has shown that flicker stimulation, especially at 40 Hz, might improve memory and brain function. One study found that this type of light flicker reduced memory problems and protected brain cells in key areas like the frontal lobe and hippocampus. Another study discovered that flicker stimulation improved working memory and strengthened brain activity patterns. Additionally, 40 Hz light flicker increased brain activity, particularly in vision-related areas. In this trial, participants will receive either flicker stimulation or sham white noise stimulation. These findings suggest that flicker stimulation could be a promising treatment for memory loss and related brain changes.36789

Who Is on the Research Team?

RS

Rachael Seidler

Principal Investigator

University of Florida

Are You a Good Fit for This Trial?

This trial is for English-speaking adults aged 65-89 who can walk unassisted, have no dementia or mild cognitive impairment, and experience subjective memory complaints. They must perform daily activities normally but have a family history of dementia. An informant to provide additional information about the participant's cognition is also required.

Inclusion Criteria

I speak English.
I can perform daily activities without any issues.
My cognitive function is normal for my age, education, and sex.
See 6 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive sensory flicker stimulation or white noise sensory stimulation three times a week for three months

12 weeks
Baseline, halfway through (1.5 months), and post-intervention (3 months)

Follow-up

Participants are monitored for changes in cognition, mobility, affect, brain structure, and blood biomarkers of Alzheimer's Disease

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Flicker Stimulation
  • Sham White Noise Stimulation

Trial Overview

The study tests if sensory flicker stimulation three times a week for three months can improve thinking skills, movement, and mood in older adults with Subjective Cognitive Decline (SCD), compared to those receiving sham white noise stimulation. It also examines brain changes and blood markers related to Alzheimer's Disease.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Placebo Group

Group I: Flicker StimulationExperimental Treatment1 Intervention
Group II: ControlPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Florida

Lead Sponsor

Trials
1,428
Recruited
987,000+

Citations

Effect of 40 Hz light flicker on cognitive impairment and ... - PMC

40 Hz light flicker treatment ameliorated memory deficits after rUCCAO and alleviated the damage to neurons in the frontal lobe and hippocampus.

Brain stimulation with 40 Hz heterochromatic flicker ...

This study introduces a new kind of heterochromatic flicker based on spectral combinations of blue, cyan, green, lime, amber, and red (BCGLAR).

Evidence that gamma rhythm stimulation can treat ...

A growing number of studies are showing beneficial clinical effects from noninvasive stimulation of gamma rhythms in the brain, but clinical ...

Flickering red-light stimulus for promoting coherent 40 Hz ...

To demonstrate the feasibility of using a lighting intervention to promote coherent 40 Hz neural oscillation, improved working memory performance, and reduced ...

40 Hz Light Flicker Alters Human Brain ...

Data demonstrated that 40 Hz light flicker significantly increased the overall brain oscillation power, particularly in the occipital areas on ...

Small studies of 40-hertz sensory stimulation confirm safety ...

A pair of early-stage clinical studies testing the safety and efficacy of 40-hertz sensory stimulation to treat Alzheimer's disease has found ...

The safety and efficacy of gamma frequency auditory ... - PMC

GFAVS appears to be well tolerated and may induce structural brain alterations in individuals with Alzheimer's disease or mild cognitive ...

Safety, Tolerability and Efficacy of 40Hz Sensory ...

Primary endpoints of the therapy showed that it was well-tolerated, showed high adherence and demonstrated a favorable safety profile. Secondary ...

Can flickering lights and sound slow Alzheimer's?

Those preliminary tests found that flickering lights and sound at 40 Hz for an hour a day had the potential to slow cognitive decline and volume ...