2 Participants Needed

Transcranial Magnetic Stimulation for Stuttering

KP
JH
Overseen ByJulio Hernandez Pavon, Ph.D., DSc
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether transcranial magnetic stimulation (TMS), which uses magnetic pulses to stimulate specific brain areas, can reduce stuttering in adults. Researchers aim to determine if these magnetic pulses will alter the brain in ways that decrease stuttering. Participants will undergo 10 TMS sessions and attend several lab visits for tests before and after the treatment. This trial suits adults who self-identify as currently stuttering and are comfortable with lab visits and TMS sessions. As an unphased trial, it offers a unique opportunity to contribute to groundbreaking research on stuttering treatment.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but it excludes people taking medications that increase the risk of seizures. It's best to discuss your specific medications with the trial team.

What prior data suggests that transcranial magnetic stimulation is safe for treating stuttering?

Research has shown that transcranial magnetic stimulation (TMS) is generally safe. Studies have found that repetitive TMS (rTMS) can improve speech in individuals with conditions like post-stroke aphasia. Importantly, these studies reported that rTMS is well-tolerated, with no serious side effects.

Minor side effects might include mild headaches or a tingling sensation at the treatment site. However, these effects are usually temporary and not serious. The use of TMS for other conditions further supports its safety.

In short, current evidence suggests that TMS is a safe and well-tolerated treatment option for improving speech.12345

Why are researchers excited about this trial?

Transcranial Magnetic Stimulation (TMS) is unique because it offers a non-invasive approach to treating stuttering by using magnetic fields to stimulate specific areas of the brain involved in speech and motor functions. Unlike traditional treatments such as speech therapy or pharmacological options, TMS directly targets the neurological pathways associated with stuttering. Researchers are excited about this treatment because it has the potential to provide quicker results and could lead to more effective management of stuttering by addressing its root cause in the brain.

What evidence suggests that transcranial magnetic stimulation is effective for treating stuttering?

Research has shown that transcranial magnetic stimulation (TMS) can help people who stutter speak more smoothly. Studies have found that techniques like TMS can reduce the frequency and severity of stuttering. TMS targets specific brain areas that control speech and movement, potentially improving speech fluency. In past studies, participants who received real TMS treatments experienced significant improvements in their stuttering. These findings suggest that TMS could be a promising method for helping individuals who stutter speak more fluently.

In this trial, participants will receive 10 days of TMS targeting specific cortical speech and motor areas to evaluate its effectiveness in treating stuttering.678910

Who Is on the Research Team?

KP

Kristin Pelczarski, Ph.D.

Principal Investigator

Kansas State University

JH

Julio Hernandez Pavon, Ph.D., DSc

Principal Investigator

Kansas State University

Are You a Good Fit for This Trial?

This trial is for adults who have developed stuttering. Participants must be able to attend multiple lab visits and complete a series of rTMS sessions. Specific eligibility criteria are not provided, but typically participants would need to meet certain health standards and not have conditions that exclude them from safely receiving rTMS.

Inclusion Criteria

Right-handed or left-handed
Self-identifies as a person who currently stutters
I am between 18 and 65 years old.
See 3 more

Exclusion Criteria

Pre-existing speech, language, or neurological disorder (except for stuttering)
Significant claustrophobia; Ménière's disease
Failure to perform the behavioral tasks or neuropsychological evaluation tests
See 18 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks
3 visits (in-person)

Pre-treatment

Participants undergo MRI and rsfMRI recordings and a neuronavigational session to prepare for TMS treatment

1 week
1 visit (in-person)

Treatment

Participants receive 10 sessions of rTMS targeting the left inferior frontal gyrus

2 weeks
10 visits (in-person)

Post-treatment

Participants undergo post-treatment assessments including rs-EEG and eye tracking

1 week
2 visits (in-person)

Follow-up

Participants are monitored for changes in stuttering and phonological processing

1 week
1 visit (in-person)

What Are the Treatments Tested in This Trial?

Interventions

  • Transcranial Magnetic Stimulation

Trial Overview

The study is testing whether transcranial magnetic stimulation (rTMS) can help reduce stuttering in adults. It involves initial assessments, ten treatment sessions with rTMS, and follow-up tests to see if there are any changes in brain activity or speech fluency.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Transcranial Magnetic Stimulation to treat stutteringExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Kansas State University

Lead Sponsor

Trials
39
Recruited
13,400+

Citations

The Effects of tDCS on Speech Fluency in People Who Stutter

Recent reviews have explored the efficacy of a wide range of neuromodulation techniques in stuttering, including transcranial magnetic ...

Brain Stimulation in Stuttering: Participant Experiences with ...

Cathodal stimulation decreases cerebral excitability by hyperpolarizing neurons while anodal stimulation increases excitability by causing ...

Speech Fluency Improvement in Developmental Stuttering ...

The findings suggest that speech fluency was generally improved in case of using real tDCS, in particular in case of its evaluation 1 week after the conclusion ...

Efficacy of Noninvasive Brain Stimulation Techniques in ...

Results: The random-effects meta-analysis revealed a significant positive effect of neuromodulation techniques on reducing stuttering severity and frequency.

Using Transcranial Magnetic Stimulation to Treat Stuttering ...

This study uses Transcranial Magnetic Stimulation (TMS) applied to specific speech and motor areas of the brain to stimulate cortical areas that experience ...

Transcranial Magnetic Stimulation (TMS): Potential Progress ...

The purpose of this article is to review the literature on electrical brain stimulation as an intervention to improve aphasia recovery.

Effects of speech rehabilitation training combined with ...

Speech rehabilitation training combined with rTMS can effectively improve speech function in PSA, with remarkable rehabilitation effects.

Long-Term Therapy With Transcranial Magnetic ...

This randomized clinical trial assesses whether long-term transcranial magnetic stimulation (TMS) combined with language therapy is ...

Efficacy and safety of repetitive transcranial magnetic ...

This study shows that rTMS can safely and effectively improve speech function in patients with post-stroke aphasia (PSA), particularly in auditory comprehension ...

Effects of Low Frequency Repetitive Transcranial Magnetic ...

1. rTMS stimulation combined with speech training can promote the improvement of speech ability in children with cerebral palsy.