taVNS for Apraxia of Speech

This trial tests a new approach to assist individuals with apraxia of speech, a condition that often makes speaking difficult after a stroke or brain injury. The study explores whether taVNS (transcutaneous auricular vagus nerve stimulation), which stimulates a nerve in the ear, can enhance speech recovery. Participants will engage in activities and treatments over 17 weeks, with some receiving a placebo (a non-active treatment) for comparison. Individuals who have experienced speech problems for at least six months following a stroke or brain injury may be suitable for this study. As an unphased trial, this study provides a unique opportunity to contribute to groundbreaking research that could lead to new treatments for speech recovery.

The trial excludes participants who are taking medications that influence key neurotransmitters, so you may need to stop taking such medications to participate.

Research has shown that transcutaneous auricular vagus nerve stimulation (taVNS), a device used to gently stimulate the ear area, is generally safe and well-tolerated. Most side effects, such as skin irritation, headaches, or a sore throat, are mild and resolve quickly. This non-invasive method, which does not involve surgery or entering the body, enhances safety. Additionally, taVNS is affordable and easy to access, making it a promising option for aiding speech recovery in conditions like apraxia of speech.¹²³⁴⁵

Researchers are excited about taVNS for apraxia of speech because it offers a non-invasive way to stimulate the vagus nerve, potentially enhancing speech therapy outcomes. Unlike traditional treatments that rely solely on speech exercises and therapy, taVNS uses mild electrical stimulation to the ear, which may improve brain function related to speech. This innovative approach could provide a complementary boost to standard interventions, offering new hope for individuals struggling with apraxia of speech.

This trial will compare non-invasive vagus nerve stimulation (taVNS) with a sham stimulation. Studies have shown that taVNS can improve movement and mental health, especially in stroke survivors. One study found that taVNS significantly increased muscle strength compared to a delayed version of the treatment. Research also suggests that taVNS can enhance cognitive function in conditions affecting the brain and mind. Additionally, taVNS has been linked to better performance in tasks requiring idea-switching. These findings suggest that taVNS might aid in speech recovery for individuals with apraxia of speech.²⁶⁷⁸⁹