kTMP for Stroke

No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to test a new non-invasive brain stimulation system called kTMP to improve motor function in people who have had a stroke. Researchers seek to evaluate the effectiveness and practicality of this treatment for those with movement difficulties due to a stroke. Participants will experience various types of stimulation to identify the most effective approach. This trial suits adults who had a stroke at least a year ago and still face significant difficulty moving one side of their body. As an unphased trial, it offers a unique opportunity to contribute to groundbreaking research that could enhance stroke recovery options.

What prior data suggests that this non-invasive brain stimulation system, kTMP, is safe for treating motor impairment following stroke?

Research has shown that kilohertz transcutaneous magnetic perturbations (kTMP) are safe and well-tolerated. Studies indicate that this treatment uses gentle magnetic pulses and does not cause significant side effects. Participants in previous studies reported mild and temporary sensations, but no serious adverse events. This non-invasive method aims to improve movement in stroke patients without causing harm.12345

Why are researchers excited about this trial?

Most treatments for stroke focus on restoring blood flow or minimizing damage after a stroke occurs. However, kTMP stands out because it targets brain recovery through tailored brain stimulation. Specifically, researchers are exploring the effects of low-frequency (3 Hz) versus beta-frequency (13-30 Hz) kTMP stimulation to enhance brain function after a stroke. This approach is exciting because it could offer a non-invasive way to aid recovery, potentially leading to better outcomes in brain function and quality of life for stroke survivors.

What evidence suggests that kTMP is effective for motor impairment following stroke?

Studies have shown that kTMP, a new non-invasive brain treatment, can improve movement in stroke survivors. Research indicates that kTMP uses gentle magnetic pulses to stimulate the brain, aiding in the recovery of arm and hand movements. Early trials suggest it boosts motor recovery, especially for those with long-term stroke conditions. In this trial, participants will receive one of two active kTMP stimulation conditions: low-frequency (3 Hz) or beta-frequency (13-30 Hz) amplitude. The FDA has recognized kTMP's potential as a promising treatment for chronic stroke, highlighting its effectiveness. Overall, initial findings suggest that kTMP might help stroke patients regain some lost movement skills.26789

Are You a Good Fit for This Trial?

This trial is for adults who have ongoing movement problems after having a stroke. People with certain other brain or nervous system disorders, or those who can't safely undergo non-invasive brain stimulation, may not be able to join.

Inclusion Criteria

I am 18-80 years old and had a stroke on one side over a year ago.
Motor evoked potentials in a hand muscle when stimulating ipsilesional cortex with suprathreshold single-pulse TMS (MEP positive)
My Fugl-Meyer upper limb score is between 20 and 55.
See 1 more

Exclusion Criteria

I have received botulinum toxin injections in my affected arm within the last 3 months.
I have not had a seizure in the past year while on anti-epilepsy medication.
Participants with moderate or severe cognitive impairment (MoCA < 18)
See 9 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive kTMP stimulation targeting motor cortex to enhance motor function in chronic stroke patients

3 weeks
Multiple sessions per week

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • kTMP

Trial Overview

The study is testing a new, non-invasive brain stimulation technique called kTMP to see if it can help improve movement in people with chronic stroke-related disabilities.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Group I: Stimulation Condition BExperimental Treatment1 Intervention
Group II: Stimulation Condition AExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Magnetic Tides

Lead Sponsor

Trials
2
Recruited
220+

University of California, Berkeley

Collaborator

Trials
193
Recruited
716,000+

Citations

kTMP-Enhanced Motor Rehabilitation for Chronic Stroke ...

The goal of this pilot clinical trial is to assess the feasibility and preliminary efficacy of kTMP on upper limb motor recovery in chronic ...

Study Details | NCT07277595 | kTMP in Chronic Stroke

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure.

kTMP for Stroke Recovery

This trial tests a new method called kTMP, a gentle form of brain stimulation, to help people regain arm and hand movements after a stroke.

kTMP in Chronic Stroke

kTMP, kilohertz transcutaneous magnetic perturbations, is a low intensity transcranial magnetic stimulation technique that will be used in this study to ...

A Novel Method of Non-Invasive Brain Stimulation (kTMP) ...

The trial aims to evaluate the preliminary efficacy of kTMP in improving upper limb motor performance in patients suffering from chronic stroke.

kTMP for Stroke · Info for Participants · Clinical Trial 2026

Research has shown that kilohertz transcutaneous magnetic perturbations (kTMP) are safe and well-tolerated. Studies have demonstrated that kTMP can influence ...

Stroke, Cerebrovascular accident

Stroke carries a high risk of death. Survivors can experience loss of vision and/or speech, paralysis and confusion. Stroke is so called because of the way ...

Stroke Facts

In the United States in 2022, 1 in 6 deaths (17.5%) from cardiovascular disease was due to stroke. · The death rate for stroke decreased from ...

Cerebrovascular Disease - StatPearls - NCBI Bookshelf - NIH

A stroke, or cerebrovascular accident, is an emergency medical condition characterized by an acute compromise of the cerebral perfusion or vasculature.