cTBS for PTSD

This trial explores a new method to potentially prevent PTSD (post-traumatic stress disorder) using a non-invasive brain stimulation technique called continuous theta burst stimulation (cTBS). The researchers aim to determine if disrupting memory processing in the brain shortly after a traumatic event can lower fear responses and reduce PTSD risks. Participants will receive either actual cTBS or a sham (placebo) version during the study. The study seeks individuals with PTSD who have no history of neurological diseases or major head trauma. As an unphased trial, it offers a unique opportunity to contribute to groundbreaking research in PTSD prevention.

Yes, you must stop taking any current psychoactive medications to participate in the trial.

Research has shown that continuous theta burst stimulation (cTBS), a type of brain stimulation, is generally safe. Although the FDA has approved it only for treating depression, studies are exploring its use for other conditions like PTSD. Most people tolerate it well, and serious side effects rarely occur. Some might experience mild discomfort or a slight headache, but these symptoms usually resolve quickly. Overall, cTBS seems to be a promising, non-invasive option with a good safety record.¹²³⁴⁵

Researchers are excited about continuous theta burst stimulation (cTBS) for PTSD because it represents a novel approach that targets the brain's sensory cortex during critical periods of memory processing. Unlike traditional treatments for PTSD, such as psychotherapy or medication like SSRIs, which often take weeks to show results, cTBS has the potential to disrupt maladaptive neural patterns swiftly. By using transcranial magnetic stimulation, cTBS aims to alter brain activity in specific areas linked to fear and memory, offering a targeted and potentially faster-acting alternative to current options.

Research has shown that continuous theta burst stimulation (cTBS) might help reduce PTSD symptoms. This technique is part of a broader method known as TMS, which has shown promise in easing PTSD by targeting specific brain areas. In this trial, some participants will receive active cTBS, while others will receive sham cTBS as a placebo comparator. Studies suggest that cTBS can improve brain cell communication, potentially alleviating PTSD symptoms. Although more research is needed, these findings indicate that cTBS could be a promising way to manage PTSD.¹⁶⁷⁸⁹