Written Exposure Therapy for Post-Traumatic Stress Disorder

Age: < 65
Sex: Any
Trial Phase: Academic
Sponsor: Medical University of South Carolina
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests the effectiveness of Written Exposure Therapy (WET) for young people aged 12 to 18 who have experienced trauma and show symptoms of post-traumatic stress disorder (PTSD). The study compares this shorter therapy to a more traditional option, Trauma-Focused Cognitive Behavior Therapy (TF-CBT). Researchers aim to adapt WET for younger people to enhance its effectiveness and accessibility. Teens who have experienced a traumatic event and currently struggle with PTSD symptoms might be suitable for this trial. Participants will be randomly assigned to either therapy and will provide feedback to improve future treatment options. As an unphased trial, this study offers a unique opportunity for participants to contribute to developing more accessible PTSD treatments for young people.

Do I need to stop my current medications to join the trial?

Participants must have their psychotropic medications (medications affecting mood, perception, or behavior) stabilized for at least two weeks before starting the study. There is no mention of needing to stop other medications.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Previous studies have shown that Written Exposure Therapy (WET) is safe for treating post-traumatic stress disorder (PTSD). Research indicates that people tolerate it well. It has also proven effective for adults with other mood issues or substance use problems. For instance, one study found that most participants continued with the therapy, and it required little extra time from therapists. Additionally, WET significantly reduced PTSD symptoms.

This therapy is generally well-received, with few reports of negative effects. Results from various settings demonstrate that WET is both flexible and effective. Since WET is already used for adults, it suggests potential safety for younger individuals as well. However, this study aims to evaluate how well WET works for those aged 12 to 18.12345

Why are researchers excited about this trial?

Written Exposure Therapy (WET) is unique because it offers a straightforward and brief approach to treating PTSD that can be completed in just a few sessions. Traditional therapies like Prolonged Exposure or Cognitive Processing Therapy often require more time and are more intensive. Unlike these standard treatments, WET involves writing about traumatic experiences, which can be done without the need for extensive verbal communication. This makes it more accessible for those who might find it hard to talk about their experiences. Researchers are excited because WET could provide an effective and less burdensome option for people with PTSD, potentially increasing the number of people who can benefit from therapy.

What evidence suggests that Written Exposure Therapy might be an effective treatment for PTSD in adolescents?

Research has shown that Written Exposure Therapy (WET), which participants in this trial may receive, effectively reduces PTSD symptoms. Studies have found that WET works as well as longer therapies but requires fewer sessions. One study reported significant improvement in PTSD and depression symptoms in adults using WET. Another study showed that few participants dropped out, indicating that WET is easy to adhere to and engaging. Overall, WET is considered a strong option for treating PTSD.678910

Are You a Good Fit for This Trial?

This trial is for adolescents aged 12 to 18 living in South Carolina who have experienced trauma and show PTSD symptoms. Participants must understand English, and those under 18 need caregiver consent.

Inclusion Criteria

2. Accompanying, consenting caregiver (exception, 18-year-olds can provide consent without accompanying caregiver)
5. A score of greater than or equal to 6 on the Child Trauma Screen (CTS)
I am between 12 and 18 years old.
See 4 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either adapted Written Exposure Therapy (WET) or Trauma-Focused Cognitive Behavior Therapy (TF-CBT). WET involves 5-7 weekly sessions, while TF-CBT involves 12-16 weekly sessions.

5-16 weeks
Weekly sessions (remote or in-person)

Follow-up

Participants are monitored for changes in mental health symptoms and diagnoses over a 30-week period following therapy engagement.

30 weeks
4 follow-up assessments at 6, 10, 20, and 30 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Written Exposure Therapy

Trial Overview

The study compares two therapies for PTSD in youth: an adapted Written Exposure Therapy (WET) with 5-7 sessions, and Trauma-Focused Cognitive Behavior Therapy (TF-CBT) with 12-16 sessions. Participants are randomly assigned to one of the treatments.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Experimental Group (Written Exposure Therapy)Experimental Treatment1 Intervention
Group II: Comparison Condition (Trauma-focused Cognitive Behavior Therapy)Active Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Medical University of South Carolina

Lead Sponsor

Trials
994
Recruited
7,408,000+

National Institute of Mental Health (NIMH)

Collaborator

Trials
3,007
Recruited
2,852,000+

Citations

A systematic review of Written Exposure Therapy for the ... - PMC

The published studies indicate that WET is an efficacious and effective treatment for PTSD symptoms across a variety of samples, settings, and counties. Future ...

Effectiveness of Written Exposure Therapy for Posttraumatic ...

Objective: Written Exposure Therapy (WET) for posttraumatic stress disorder (PTSD) has been shown to be efficacious in clinical trials; however, ...

Written Exposure Therapy vs Prolonged ...

The accumulating evidence for WET suggests that it may be an efficacious and effective PTSD treatment that is associated with less treatment ...

Written Exposure Therapy for the Treatment of ...

The evidence indicates that WET is an efficacious and effective treatment approach for PTSD and is noninferior to more time-intensive evidence-based treatments ...

Study Finds Written Exposure Therapy Effective Option For ...

“Participants suffering from posttraumatic stress disorder improved significantly using both prolonged exposure and written exposure therapies,” ...

Identifying Predictors of Long-Term Treatment Outcomes ...

In CPT, higher levels of negative emotion and positive view of self, as well as lower levels of hopelessness, predicted better long-term treatment outcome at 60 ...

Written Exposure Therapy for PTSD - PTSD: National Center ...

Findings to date indicate WET is safe and effective for PTSD patients with comorbid mood disorder symptoms, (4,6, 24-27) substance use disorders, (28,29), ...

A pilot study of twice-weekly group-based written exposure ...

Findings demonstrate that brief, group-delivered WET is feasible and shows promise for addressing PTSD and depressive symptoms in residential SUD treatment.

Posttraumatic stress disorder in adults: Psychotherapy and ...

Written exposure therapy has also been shown to be effective in the treatment of PTSD [8,9]. Trauma-focused therapies focus on the trauma and ...

Full article: Feasibility of written exposure therapy for PTSD ...

Written Exposure Therapy (WET) was feasible and well-tolerated in a routine psychiatric outpatient setting, with high adherence and minimal therapist time. The ...