Spinal Cord Stimulation for Spinal Cord Injury

This trial explores whether non-invasive spinal cord stimulation, specifically Spinal Cord Transcutaneous Stimulation, can help regulate blood pressure in individuals with chronic spinal cord injuries. Researchers aim to determine if stimulating specific spinal cord areas can improve blood pressure control and affect the enzymes involved in its regulation. Participants will receive stimulation through electrodes placed on their skin. This trial suits individuals with a stable spinal cord injury for over a year who experience low blood pressure symptoms. As an unphased trial, it offers participants the chance to contribute to groundbreaking research that could lead to new treatments for blood pressure issues related to spinal cord injuries.

The trial information does not specify if you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research has shown that transcutaneous spinal cord stimulation (tSCS) is generally safe for people with spinal cord injuries. In one study, 88.5% of sessions had no negative effects. Some minor issues, such as changes in heart rate or blood pressure, have been reported but remain uncommon. Another study confirmed the safety of tSCS, especially when combined with rehabilitation, and found it improved muscle strength without serious side effects.

For the CV-scTS 1 treatment, evidence suggests that tSCS is safe and can enhance leg function and walking speed, with few safety concerns. The Resp-scTS treatment also appears safe. Studies have demonstrated that using tSCS in the mid-back area is safe and practical, even for children.

Researchers are excited about spinal cord transcutaneous stimulation (scTS) for spinal cord injury because it offers a non-invasive approach to improving blood pressure regulation and respiratory function, which are major challenges for patients with spinal cord injuries. Unlike standard care options like medication and physical therapy, scTS directly targets specific spinal cord levels using electrical stimulation to enhance autonomic functions. This method allows for precise mapping and adjustment of stimulation parameters, potentially leading to personalized treatment plans that could significantly improve quality of life for individuals with spinal cord injuries. With its innovative mechanism of action, scTS could represent a breakthrough in how these injuries are managed.

This trial will evaluate spinal cord transcutaneous stimulation (scTS) for individuals with spinal cord injuries. Participants will receive scTS at various spinal levels in different trial arms. Studies have shown that scTS can stabilize blood pressure, especially when applied to the lower and mid-back areas, aiding heart control and blood pressure improvement. Additionally, scTS applied to the upper back has improved breathing and muscle strength. While more research is needed, these findings suggest that spinal cord stimulation may help manage blood pressure and support breathing health in individuals with spinal cord injuries.⁶⁷⁸⁹¹⁰