Activity-Based Therapy for Spinal Cord Injury

(PROMPT-SCI II Trial)

This trial tests an early exercise therapy called Activity-Based Therapy, which uses a sitting leg cycling machine for individuals with spinal cord injuries. The researchers aim to determine if starting this exercise within the first week post-injury can reduce complications and improve recovery over the following year. Individuals who have experienced a non-penetrating spinal cord injury and underwent spine surgery within 48 hours may be suitable candidates for this trial. The goal is to enhance motor and sensory functions, as well as bladder and bowel control, often affected by such injuries. As an unphased trial, this study offers participants the chance to contribute to pioneering research that could improve recovery outcomes for future patients.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research has shown that activity-based therapy (ABT) for spinal cord injuries is safe. One study found that starting ABT soon after a spinal cord injury, within a few days, did not cause serious problems, and participants tolerated it well. Another report indicated that patients in an ABT program rated it highly, with most giving scores of 8 out of 10 or higher. Evidence also suggests that ABT can improve independence and functional ability. This indicates that people generally tolerate the therapy well, and it does not cause harm.¹²³⁴⁵

Activity-based therapy is unique because it involves leg cycling, which directly stimulates the muscles and nerves below the site of the spinal cord injury. Unlike traditional rehabilitation methods that often focus on compensating for lost function, this therapy aims to reactivate and strengthen the neural pathways and muscles. Researchers are excited about this approach because it holds the potential to improve mobility and independence for individuals with spinal cord injuries by promoting natural, functional recovery.

Research has shown that activity-based therapy (ABT), which participants in this trial will receive, can help people with spinal cord injuries (SCI) improve. Studies have found that intense physical therapy can boost mobility and function in those with SCI. Specifically, one study found that ABT improved sitting balance, movement, and quality of life for people with long-term SCI. Another study suggested that ABT can aid in walking and support nerve recovery. Overall, promising evidence indicates that ABT can enhance functional outcomes for people with SCI.²⁶⁷⁸⁹