Speech Production Tasks for Speech and Language Disorders

Age: < 65
Sex: Any
Trial Phase: Academic
Sponsor: Lingyun Zhao
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

Speech and communication disorders often result in aberrant control of the timing of speech production, such as making improper stops at places where they should not be. During normal speech, the ability to stop when necessary is important for maintaining turn-taking in a smooth conversation. Existing studies have largely investigated neural circuits that support the preparation and generation of speech sounds. It is believed that activity in the prefrontal and premotor cortical areas facilitates high-level speech control and activity in the ventral part of the sensorimotor cortex controls the articulator (e.g. lip, jaw, tongue) movements. However, little is known about the neural mechanism controlling a sudden and voluntary stop of speech. Traditional view attributes this to a disengagement of motor signals while recent evidence suggested there may be an inhibitory control mechanism. This gap in knowledge limits our understanding of disorders like stuttering and aphasia, where deficits in speech timing control are among the common symptoms. The overall goal of this study is to determine how the brain controls the stopping of ongoing speech production to deepen our understanding of speech and communication in normal and impaired conditions.

Who Is on the Research Team?

LZ

Lingyun Zhao, PhD

Principal Investigator

University of Pittsburgh

Are You a Good Fit for This Trial?

This trial is for people with speech and language disorders, epilepsy, or autism spectrum disorder. There are no detailed inclusion or exclusion criteria listed.

Inclusion Criteria

My vision is normal or corrected to normal with glasses or contacts.
My thinking, speech, and hearing abilities are normal.
I am having iEEG electrodes placed in my brain for epilepsy or language mapping.
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Exclusion Criteria

Individuals with intellectual disability
Lack of fluent English comprehension/production
History of autism or ADHD
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What Are the Treatments Tested in This Trial?

Trial Overview

The study examines how the brain controls stopping ongoing speech by having participants perform specific speech production tasks. It aims to better understand normal and disordered speech control.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Voice and iEEG recording during Speech Production TasksExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Lingyun Zhao

Lead Sponsor

National Institute on Deafness and Other Communication Disorders (NIDCD)

Collaborator

Trials
377
Recruited
190,000+