Eccentric Resistance Exercise for Skeletal Muscle Response
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to understand how thigh muscles react to eccentric resistance exercise, which involves lengthening the muscle while it contracts. Researchers measure certain biomarkers in the muscle to assess how this exercise affects muscle inflammation. Individuals aged 18-35 who are healthy and engage in regular moderate to vigorous exercise may be suitable for this study.
As an unphased study, this trial offers a unique opportunity to contribute to the scientific understanding of muscle health and exercise.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What prior data suggests that this exercise protocol is safe?
Research has shown that eccentric resistance exercise is generally safe. However, incorrect execution can lead to muscle soreness and even muscle damage. This exercise involves stretching the muscle while it is working, which can challenge the muscles. Some studies have found that after just one session, participants might feel more tired or experience temporary muscle weakness. Despite these effects, eccentric exercise is known to improve strength and some heart health markers over time. Following the exercise instructions carefully can reduce potential discomfort.12345
Why are researchers excited about this trial?
Researchers are excited about eccentric resistance exercise for muscle response because it focuses on the lengthening phase of muscle contraction, which is different from traditional resistance exercises that emphasize muscle shortening. This method uses an isokinetic dynamometer to perform 300 eccentric knee extensions, potentially offering a more efficient way to build muscle strength and mass. Unlike typical resistance exercises that can lead to quicker fatigue, eccentric training might allow for greater muscle overload with less energy expenditure, making it a promising alternative for improving muscle health and rehabilitation outcomes.
What evidence suggests that eccentric resistance-exercise is effective for skeletal muscle response?
Research shows that eccentric resistance exercise, which participants in this trial will perform, can increase muscle strength and function. This type of exercise has improved strength in various groups, including stroke patients. Eccentric exercise involves muscles lengthening as they contract, leading to better strength gains compared to traditional exercises. Studies have found that it can also benefit heart health. Overall, eccentric resistance training effectively boosts muscle performance and strength.14567
Who Is on the Research Team?
Stephen M Cornish, PhD
Principal Investigator
University of Manitoba
Are You a Good Fit for This Trial?
This trial is for individuals who are interested in participating in a study to understand how their thigh muscles respond after doing specific resistance exercises that involve muscle lengthening during contraction. The details about who can join or reasons why someone might not be able to participate are not provided.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Pre-Exercise Rest
Participants rest for 30 minutes before exercise and provide a baseline muscle biopsy
Exercise
Participants perform 300 repetitions of maximal isokinetic eccentric knee extensions
Post-Exercise Rest
Participants rest for 3 hours post-exercise before a second muscle biopsy is taken
Follow-up
Participants are monitored for safety and effectiveness after the exercise intervention
What Are the Treatments Tested in This Trial?
Interventions
- Eccentric resistance-exercise
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Manitoba
Lead Sponsor