Personalized Exercise Program for Sarcoma

(AYA-ONE Trial)

This trial aims to help adolescents and young adults with sarcoma (a type of cancer) improve their physical function and quality of life through a personalized exercise program. Researchers seek to determine if the Exercise Triage and Personalized Exercise Program can effectively direct participants to appropriate exercise and rehabilitation services. The trial seeks participants who have sarcoma, have received treatment at the DFCI Sarcoma Center or Jimmy Fund, and speak English. As an unphased trial, this study offers a unique opportunity for participants to contribute to innovative research that could enhance future care strategies.

Research has shown that personalized exercise programs are generally safe for people with cancer, including those with sarcoma. Studies have found that these programs can enhance physical abilities and quality of life without causing harm. Exercise is often recommended as part of cancer care because it can reduce fatigue and boost overall health.

Participants in previous personalized exercise programs reported few negative effects, indicating that most handled the exercises well without major issues. In cancer treatment, exercise is considered a safe and effective way to support recovery and improve outcomes.

Researchers are excited about the Personalized Exercise Program for sarcoma because it offers a tailored approach to treatment that differs significantly from traditional methods like surgery, chemotherapy, and radiation. Most standard treatments focus directly on attacking the cancer cells, but this program aims to improve patients' overall physical health, potentially enhancing their quality of life and response to conventional treatments. By customizing exercise regimens to each patient's needs and capabilities, this approach could offer a more holistic method of care, supporting both physical and mental well-being during treatment.

Research has shown that personalized exercise programs can greatly benefit cancer patients. For instance, studies have found that exercise can lower the risk of cancer recurrence and extend patients' lives. One study discovered that patients who followed a structured exercise program had an 80% chance of remaining cancer-free five years later. Exercise also correlates with better physical fitness, improved quality of life, and increased physical activity. Personalized exercise programs might also help reduce cancer symptoms and enhance overall well-being. In this trial, all participants will receive an Exercise Triage and Personalized Exercise Program, which could benefit teenagers and young adults with sarcoma.¹³⁴⁶⁷