300 Participants NeededMy employer runs this trial

Immune Defense Protein for Common Cold

NC
AG
Overseen ByAzure Grant

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to determine how an Immune Defense Protein (IDP®) supplement might reduce the length and severity of common cold symptoms in older adults during the cold and flu season. Researchers also seek to observe whether the supplement affects the need for other medications, improves quality of life, and is generally well-tolerated. Participants will receive either a 50mg dose, a 200mg dose, or a placebo. This trial suits individuals aged 60 or older who frequently experience upper respiratory symptoms like coughing and sneezing during the cold season and can use a smartphone for the study app. As an unphased trial, it offers a unique opportunity to contribute to understanding the potential benefits of IDP® for improving health during the cold season.

Do I need to stop my current medications to join the trial?

The trial does not specify if you need to stop taking your current medications. However, if you are on certain immunosuppressive therapies or have specific health conditions, you may not be eligible to participate.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that the Immune Defense Protein (IDP) being tested for the common cold is generally safe. Although direct data from past human trials is lacking, similar proteins have shown promise in boosting immunity without major issues. For instance, studies have examined how certain proteins can help the immune system combat the common cold effectively, and these studies did not report any serious side effects.

This trial is marked as "Not Applicable" for phase, indicating it is likely in the early stages. Early-stage treatments are typically monitored closely for safety, and serious side effects are rare if the study has reached this point. This should provide some reassurance about the product's safety as researchers continue to study its effects on cold symptoms.12345

Why are researchers excited about this trial's treatments?

Researchers are excited about the Immune Defense Protein because it represents a novel approach to tackling the common cold. Unlike standard options like decongestants and antihistamines, which alleviate symptoms, this treatment focuses on boosting the body's immune response with a specific protein. The study includes two different doses, 50mg and 200mg, potentially allowing for tailored treatment based on individual needs. This immune-targeting strategy could mean faster recovery times and reduced symptom severity, making it a promising alternative to current symptom-focused remedies.

What evidence suggests that the Immune Defense Protein might be an effective treatment for the common cold?

Research has shown that certain proteins play a crucial role in protecting against respiratory viruses like the common cold. One study found that a combination of two proteins, lactoferrin and immunoglobulin, significantly reduced cold symptoms. Other studies have discovered proteins that enhance the body's ability to recognize and combat cold viruses. These findings suggest that the Immune Defense Protein, which participants in this trial may receive, could help shorten and lessen cold symptoms by boosting the body's natural defenses. The evidence is promising, but further research is needed to confirm these effects, especially for older adults.26789

Are You a Good Fit for This Trial?

This trial is for adults aged 60 and older in the US who get upper respiratory symptoms (like coughing or congestion) at least 2-3 times during cold/flu season, can use a smartphone app, and do not have serious illnesses, immune problems, asthma/COPD, daily cannabis/nicotine use, or allergies to milk products.

Inclusion Criteria

Able to read, understand, and provide informed consent
Able to use a personal smartphone device and download Chloe by People Science
Able to receive shipment of the product at an address within the United States
See 3 more

Exclusion Criteria

I do not have other health conditions that could affect study results.
Have a significant illness, disease or condition which, in the opinion of the principal investigator, may impact their ability to participate in the study or impact the study outcomes
Use of cannabis-containing products daily
See 8 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either the IDP® Supplement or a placebo to evaluate its impact on upper respiratory symptoms, rescue medication use, and quality of life

17 weeks
Self-reported measures and questionnaires completed at home via the Chloe App

Follow-up

Participants are monitored for safety and effectiveness after treatment, focusing on the tolerability of the IDP® Supplement

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Immune Defense Protein

Trial Overview

The study tests two doses of an Immune Defense Protein supplement (50mg and 200mg) versus a placebo to see if it helps reduce the length and severity of cold or flu symptoms. Participants report their experiences from home using a mobile app.

How Is the Trial Designed?

3

Treatment groups

Experimental Treatment

Placebo Group

Group I: Group 2: Study Product 200mg DoseExperimental Treatment1 Intervention
Group II: Group 1: Study Product 50mg DoseExperimental Treatment1 Intervention
Group III: Group 3: Matching PlaceboPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Quantec Ltd

Lead Sponsor

People Science, Inc.

Industry Sponsor

Trials
7
Recruited
730+

Citations

Common cold - PMC

The common cold is a unique human disease, as it is arguably the most common disease and because of the large number of respiratory viruses causing colds

The clinical efficacy of a bovine lactoferrin/whey protein Ig ...

These findings demonstrate that the Lf/IgF combination significantly decreased the incidence of colds and the cumulative number of cold-related symptoms over ...

Researchers Identify Protein Critical for Flu Defense

Infectious disease researchers at the University of Georgia have identified a signaling protein critical for host defense against influenza infection.

A Newly Identified Protein May Be the Key to Vanquishing ...

Inactivating this protein in human cells and mice provided immunity to a range of viruses, but an effective treatment is still a long way off.

Self-Care for Common Colds: The Pivotal Role of Vitamin D ...

Vitamins C and D, zinc, and Echinacea have evidence-based efficacy on these immune system barriers. This review includes 82 eligible studies.

Temperature-dependent innate defense against the common ...

Most isolates of human rhinovirus, the common cold virus, replicate more robustly at the cool temperatures found in the nasal cavity (33–35 °C) than at core ...

Cold exposure protects from neuroinflammation through ...

Cold exposure decreases MHCII on monocytes at steady state and in various inflammatory mouse models and suppresses T cell priming and pathogenicity.

Cross-Reactive Immune Responses toward the Common ...

A new, murine study designed to examine cross-reactive immune responses between SARS-CoV-2 and common cold HCoVs (represented by prototypes OC43, HKU1, 229E, ...

Scientists discover role of protein in detecting the common ...

Scientists uncover how a sensor protein activates our immune system against the common cold. The findings may lead to more effective treatments of flu-like ...