Tumor Testing Approach for Pediatric Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This study is looking to learn whether a tumor testing approach can feasibly measure antibody-drug conjugate (ADC) target proteins in children and young adults with relapsed or refractory solid tumors or central nervous system (CNS) tumors.
The tumor testing approach is a two-step tumor profiling process of:
* Screening with bulk RNA sequencing to see which ADC target genes are turned on in the tumor.
* Confirmatory immunohistochemistry (IHC) for targets that show positive expression on the RNA screen, to confirm protein expression.
Who Is on the Research Team?
Steven Dubois, MD,MS
Principal Investigator
Dana-Farber Cancer Institute
Are You a Good Fit for This Trial?
This trial is for children and young adults who have solid tumors or brain/CNS tumors that have come back or haven't responded to treatment.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Trial Overview
Researchers are testing if they can reliably measure certain proteins in tumor samples using a two-step process: first, checking gene activity with RNA sequencing, then confirming protein presence with immunohistochemistry (IHC).
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Participants who have received ADC therapy as part of routine clinical care will submit specimens for targeted IHC testing and clinical data collection. No RNA sequencing will be performed, and IHC results will not be returned
Participants with relapsed/refractory solid or CNS tumors will undergo eligibility screening, specimen submission, bulk RNA sequencing, and confirmatory IHC testing. IHC results will be returned to the enrolling provider
Find a Clinic Near You
Who Is Running the Clinical Trial?
Dana-Farber Cancer Institute
Lead Sponsor
B+ Foundation
Collaborator
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