Non-Contrast Chest CT for Pulmonary Embolism
What You Need to Know Before You Apply
What is the purpose of this trial?
We are doing the research to see if a CT scan without the dye can help find pulmonary emboli. If you agree to join the study, you will be asked to sign this consent form before we do any research procedures. If you join the research, we will ask you to blow into a small device known as a spirometer to train you to hold your breath after you inhale and exhale. Spirometer is a small handheld device to find out how well your lungs work when you inhale and exhale. For this research, we will obtain two extra sets of CT images at very low levels of radiation dose. The two extra sets of images will take less than 1 minute. Your total participation time is about 5 minutes. We will also review your medical record for up to 30 to 90 days after your CT scan.
The main risks of being in the study are exposure to ionizing radiation which may have health risks, and minor inconvenience from the spirometer test.
You will not benefit from taking part in this research study. If you take part in this study, your participation may help people in the future. If you decide not to be in the study, you will still have the standard-of-care chest CT with the dye ordered by your doctor. You will not be paid for taking part in this research study.
Are You a Good Fit for This Trial?
This trial is for adults age 21 or older who are getting a chest CT scan with dye to check for possible blood clots in the lungs (pulmonary embolism), can give written consent, and have no major problems with memory or thinking.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Imaging Procedure
Participants undergo a non-contrast CT scan and spirometer test
Follow-up
Participants' medical records are reviewed for up to 30 to 90 days after the CT scan
What Are the Treatments Tested in This Trial?
Trial Overview
The study is testing if an extra low-dose CT scan without contrast dye can help detect lung blood clots. Participants will do simple breathing tests and get two quick, low-radiation scans in addition to their regular care.
How Is the Trial Designed?
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Treatment groups
Experimental Treatment
Patients will undergo an additional low dose CT image acquistion without contrast prior to CT pulmanary angiogram. The low dose CT will be performed in both inspiration and expiration.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Massachusetts General Hospital
Lead Sponsor
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