Laryngoscopy Methods for Neonatal Respiratory Distress Syndrome

(VID LISA Trial)

This trial explores two methods to help preterm babies with breathing problems by administering a medicine called surfactant. Researchers aim to determine whether using a video laryngoscope (a camera) or direct laryngoscopy (without a camera) is more effective for successful first-attempt administration. They also assess any additional benefits each method might offer. This trial targets preterm babies born at or before 28 weeks who have received initial breathing support and require surfactant within the first 36 hours after birth. As an unphased trial, it provides a unique opportunity to contribute to important research that could enhance care for preterm infants.

The trial information does not specify whether participants need to stop taking their current medications.

Studies have shown that using video laryngoscopy during a less invasive method of administering surfactant to newborns appears promising. Research indicates that video laryngoscopy increases the likelihood of success on the first attempt and may reduce the risk of complications compared to traditional methods. It has been associated with shorter durations of breathing support and oxygen use.

Researchers are excited about exploring different laryngoscopy methods for treating Neonatal Respiratory Distress Syndrome because these techniques could improve the way surfactant is administered to babies. Video laryngoscopy offers a unique advantage by using a camera to provide a clearer view of the vocal cords, which could lead to more accurate placement of the LISA catheter. On the other hand, direct laryngoscopy, while more traditional, doesn't rely on a camera and could be quicker in emergency situations. By comparing these two methods, researchers hope to find out which is more effective or safer, potentially leading to better outcomes for newborns with this serious condition.

This trial will compare two methods for placing a breathing tube in newborns with respiratory distress syndrome: video laryngoscopy and direct laryngoscopy. Research has shown that video laryngoscopy helps doctors place a breathing tube in a newborn's windpipe more successfully on the first try. Specifically, one study found that video laryngoscopy improved first attempt success rates by 46% compared to the traditional method, direct laryngoscopy. This method often makes it easier and more effective for doctors to see where to place the tube. In contrast, direct laryngoscopy has been less successful, particularly for doctors in training. Overall, video laryngoscopy may provide a safer and more effective way to assist preterm babies with breathing problems.¹²³⁵⁶