Exercise Intervention for Primary Immunodeficiency
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial examines whether a 12-week exercise program is safe and beneficial for adults with primary antibody deficiencies. The goal is to determine if exercise can enhance quality of life and improve immune system function. An app-based exercise intervention facilitates easy participation. Individuals with specific antibody issues, not on certain medications or treatments, may be suitable candidates, particularly if they can commit to moderate exercise.
As an unphased trial, this study provides a unique opportunity to contribute to understanding how exercise can enhance immune health.
What prior data suggests that this exercise intervention is safe for adults with primary antibody deficiencies?
Research has shown that regular exercise can benefit people with immune disorders by boosting mood, self-esteem, and overall well-being. It is generally safe for most individuals, including those with primary antibody deficiencies (PAD), a condition where the body struggles to produce antibodies.
Although specific data on the safety of an app-based exercise program is lacking, exercise programs are typically well-tolerated. Research does not mention any specific negative effects of exercise for people with PAD. This suggests that the app-based exercise program is likely safe for participants. However, it is always important to follow the advice of the healthcare team involved in the trial.12345Why are researchers excited about this trial?
Unlike the standard care for primary immunodeficiency, which often involves regular immunoglobulin infusions or antibiotics, this new app-based exercise intervention offers a unique approach by incorporating physical activity into treatment. Researchers are excited about this method because it uses a digital platform to encourage regular exercise, which could enhance immune function and overall health without the need for additional medications. This approach is innovative not just for its delivery method via an app, but also for its potential to empower patients to actively participate in their own health management.
What evidence suggests that this app-based exercise intervention is effective for primary immunodeficiency?
Research has shown that exercise can improve the quality of life for individuals with various health issues, including primary antibody deficiencies. One study found that low to moderate exercise can reduce stress and fatigue, common problems for those with immune deficiencies. This type of exercise also correlates with better overall health. In this trial, participants will engage in a 12-week, app-based exercise program designed to facilitate regular activity and potentially strengthen the immune system. Although specific data on this program remains limited, early indications suggest that regular exercise can be beneficial.16789
Who Is on the Research Team?
Ryan Steele, DO, MSc
Principal Investigator
Yale University
Are You a Good Fit for This Trial?
This trial is for adults diagnosed with primary immunodeficiency (specifically antibody deficiencies). Participants should be able to use a smartphone or similar device for an app-based exercise program.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Exercise Intervention
Participants engage in a 12-week exercise program using a mobile application, with exercise activity tracked and symptoms or infections reported
Follow-up
Participants are monitored for safety and effectiveness after the exercise intervention, including assessments and blood sample collection
What Are the Treatments Tested in This Trial?
Interventions
- App-based exercise intervention
Trial Overview
The study is testing a 12-week exercise program delivered through an app. It aims to see if this type of exercise plan is safe, practical, and helpful in improving quality of life and immune function in people with immunodeficiency.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
12-week, app-based exercise intervention in adults with primary antibody deficiencies with completion of survey procedures and collection of clinical and laboratory data
Find a Clinic Near You
Who Is Running the Clinical Trial?
Yale University
Lead Sponsor
The Pump
Collaborator
Citations
Clinical Validation of a Primary Antibody Deficiency Screening ...
The diagnostic delay of primary antibody deficiencies (PADs) is associated with increased morbidity, mortality, and healthcare costs.
Treatment and management of primary antibody deficiency ...
This evidence-based clinical guideline provides consensus-recommendations for the treatment and care of patients with primary antibody ...
The Impact of Exercise on Stress, Fatigue, and Quality ...
This aim of this research project is to determine if low to moderate level exercise can have an impact on stress, fatigue, and quality of life for individuals ...
Evaluation of Adult Patients With Immunodeficiency Within ...
This study aimed to evaluate the body structure function, activity and participation limitations of adult immunodeficiency patients within the ...
5.
primaryimmune.org
primaryimmune.org/resources/news-articles/grantees-probe-biology-aid-primary-immunodeficiency-diagnosisGrantees probe biology to aid primary immunodeficiency ...
The funded projects each work towards reducing the time to diagnosis for those with primary immunodeficiencies (PIs), also known as inborn ...
Clinical disparity of primary antibody deficiency patients ... - PMC
our data demonstrates reduced IRT usage and increased bronchiectasis prevalence at a safety net hospital,
Exercise and Immune Disease
Proper and regular exercise has been proven to help improve mood, self-esteem and intimacy; exercises, as well as the recommended precautions
baseline results from a prospective observational study - PMC
PID category was primary antibody deficiency (56.3% of patients). Complications were common, especially recurrent respiratory tract infections (63.4%). PPS, ...
Clinical Validation of a Primary Antibody Deficiency ...
We aimed to clinically validate and optimize the PAD screening algorithm by applying it to a primary care database in the Netherlands.
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