Postbiotic Supplement for Premenopause

(RESW101 Trial)

This trial tests a postbiotic supplement to determine its effectiveness in improving menopausal symptoms in women before menopause. Researchers aim to find out if taking the supplement daily for eight weeks results in a noticeable difference compared to a placebo (a pill with no active ingredients). Women who are generally healthy, aged 35 to 55, and not currently on hormone replacement therapy may be suitable candidates for this study. Participants will complete questionnaires to report their symptoms throughout the trial. As an unphased trial, this study offers participants the chance to contribute to groundbreaking research that could lead to new solutions for menopausal symptoms.

The trial does not specify if you need to stop taking your current medications, but you must avoid other probiotic, prebiotic, hormonal, or menopause-support supplements during the study.

Research has shown that postbiotic supplements are generally safe for healthy individuals. Studies have found that probiotics, which are similar to postbiotics, can be safely used by those without immune system issues. For instance, a review of several studies found that probiotics had positive effects on menopausal symptoms and were safe to use. Another study noted that a specific postbiotic, L. gasseri CP2305, may help improve women's physical and emotional well-being, indicating it is well-tolerated.

Most treatments for premenopause focus on hormone replacement therapy or lifestyle changes to manage symptoms. However, this postbiotic supplement is unique because it introduces beneficial compounds produced by gut bacteria, which may help balance hormones naturally. Researchers are excited about its potential to enhance gut health and, in turn, improve overall hormonal balance without the need for synthetic hormones or drastic lifestyle changes. This approach could offer a more natural and gentle alternative to managing premenopausal symptoms.

Research has shown that postbiotic supplements might help with menopausal symptoms. For example, one study found that a specific postbiotic, L. gasseri CP2305, improved sleep, reduced stress, and boosted emotional well-being in menopausal women. Another study discovered that probiotics enhanced overall quality of life during menopause, including reducing anxiety and depression. Additionally, a review of several studies suggests that probiotics positively impact menopausal symptoms, such as urogenital and bone health. This trial will evaluate the effectiveness of a postbiotic supplement for managing symptoms in premenopausal women, with participants receiving either the supplement or a placebo.¹²³⁴⁵