Prenatal Exercise for Childhood Obesity
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine which type of exercise—aerobic (cardio), resistance (strength), or a combination of both—best enhances health for pregnant women who are overweight or obese and their babies. Researchers seek to discover if these exercises can improve heart and metabolic health for both mothers and infants, potentially reducing obesity in the next generation. Pregnant women with a single baby, who are overweight or obese, and have their doctor's approval to exercise, might be suitable candidates for this study. As an unphased study, this trial provides a unique opportunity to contribute to significant research that could benefit future generations.
Will I have to stop taking my current medications?
The trial requires that participants do not use certain medications, such as oral hypertensive drugs and insulin, so you may need to stop taking these if you are currently using them.
What prior data suggests that these exercise modes are safe for pregnant women and their infants?
Research shows that exercise during pregnancy is generally safe and beneficial for most women. Studies have found that resistance exercises are well tolerated by both the mother and the baby, without harming the baby's health. One study found that moderate aerobic exercise does not negatively affect healthy pregnant women. However, overexertion could impact the baby's well-being.
When combining aerobic and resistance exercises, evidence suggests that moderate-intensity exercise is safe and may even benefit both the mother and the baby. This involves exercising about 3 to 4 times a week. Overall, these types of exercise carry minimal risks for expecting mothers and their babies.12345Why are researchers excited about this trial?
Researchers are excited about these exercise protocols because they target childhood obesity starting from pregnancy, which is a novel approach. Unlike typical interventions that focus on diet or post-birth exercise for children, these exercise modes engage the mother during pregnancy. The Resistance Exercise (RE), Aerobic Exercise (AE), and Combination Exercise (AERE) treatments uniquely adhere to established guidelines while varying the type and sequence of physical activity, potentially impacting the child's long-term health outcomes. By exploring these varied exercise methods during pregnancy, researchers aim to discover how prenatal activity can influence childhood weight and health, offering a proactive step in obesity prevention.
What evidence suggests that this trial's exercise modes could be effective for improving maternal and infant cardiometabolic health?
Studies have shown that exercising during pregnancy can greatly benefit both mothers and their babies. In this trial, participants will join different exercise groups: Resistance Exercise (RE), Aerobic Exercise (AE), a Combination Exercise (AERE) group, or a Control group with no exercise. Research indicates that strength training and aerobic exercises can reduce the risk of gestational diabetes and help control weight gain in pregnant women who are overweight or obese. For babies, early findings suggest that when mothers exercise, especially by combining aerobic and strength exercises, it can improve their heart health and body fat levels. Initial data also suggests that this combination of exercises might be particularly effective at lowering the risk of childhood obesity by boosting metabolism. Overall, regular exercise during pregnancy is believed to lead to healthier outcomes for both mother and child.678910
Who Is on the Research Team?
Linda E May, PhD
Principal Investigator
PI
Are You a Good Fit for This Trial?
This trial is for overweight or obese pregnant women aged 18-40, with a BMI of 25 or higher and in their first 16 weeks of a single pregnancy. They must have clearance from their obstetric provider to exercise. Excluded are those under 18 or over 40, with medical conditions like HIV/AIDS, diabetes, untreated hypertension, thyroid disorders, or who use tobacco, alcohol, drugs.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Pregnant women participate in exercise interventions (aerobic, resistance, or combination) or no exercise from approximately 13 to 40 weeks of gestation
Follow-up
Participants and their infants are monitored for cardiometabolic health outcomes at 1, 6, and 12 months postpartum
What Are the Treatments Tested in This Trial?
Interventions
- Exercise Modes
Find a Clinic Near You
Who Is Running the Clinical Trial?
East Carolina University
Lead Sponsor